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Reference the following molecule: 1-stearoyl, 2-lenoleoyl(18:2Δ9,12) phosphatidylcholine. Q: draw the platelet-activating factor. Explain the physiological relevance...

Reference the following molecule: 1-stearoyl, 2-lenoleoyl(18:2Δ9,12) phosphatidylcholine.

Q: draw the platelet-activating factor. Explain the physiological relevance of each lipid in the molecule.

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Answer #1

Please see the attached file for the Platelet activating factor using 1-stearoyl, 2-lenoleoyl(18:2Δ9,12) and phosphatidylcholine as reference molecule. Image shows, standard phosphoytidylcholine on one side and on the other side is platelet activating factor using 1-stearoyl (in Red box), 2-lenoleoyl(18:2Δ9,12)(in Green box) and phosphatidylcholine (the remaining part of molecule) as reference molecule.

C1 carbon is strearic acid (saturated fatty acid) which is connected by an ether linkage.

C2 carbon is linoleic acid (unsaturated fatty acid) whose short length because of double bond increases the solubility of PAF allowing it to function as a soluble signal messenger.

C3 is standard phosphatidylcholine

This structure allows platelet activating factor to inhabitat and freely move in lipid bilayer. The fatty acid componen aslo allows it to interact with lipoproteins.Phosphatidy Scholine. 1-Stearoyl-2- linoleoyl phophatidylcholine c oock Linoleic acid Coo-ch o=2 o p -o- CH₂ CH₃NH₂ Stearic

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Reference the following molecule: 1-stearoyl, 2-lenoleoyl(18:2Δ9,12) phosphatidylcholine. Q: draw the platelet-activating factor. Explain the physiological relevance...
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