Two
regions of Lovastatin that interact with the enzyme are indicated,
“A” and “B”. What type of amino acid residues would you most likely
find on HMG-CoA reductase that would contact these two regions?
Would they be polar or nonpolar? Justify your answer
Homework Answers
ANSWER
The answer to this question lies in the structure of the enzyme, HMG-CoA reductase. It is a membrane-anchored enzyme of endoplasmic reticulum which participates in the breakdown of HMG-CoA into mevalonate or mevalonic acid in the cholesterol synthesis pathway. It spans the membrane seven times and forms two regions, one is N-terminal domain and the other is C-terminal domain. Since, both these domains are hydrophobic in nature, the amino acids present on HMG-CoA reductase would be non-polar in nature. Thus HMG-CoA reductase tend to interact with lovastatin with the help of non-polar or hydrophobic amino acids.
Add Answer to:
Two
regions of Lovastatin that interact with the enzyme are indicated,
“A” and “B”. What type...
7. Hemoglobin, which carries oxygen to the cell, is an example b. storage of what type...
7. Hemoglobin, which carries oxygen to the cell, is an example b. storage of what type of protein? d. transport c. hormone a. structural 8. An essential amino acid is an amino acid that a. must be provided in the diet. c. does not exist as a zwitterions. b. is missing from the diet d. is synthesized in the body. 9. This amino acid would be: a nonpolar and hydrophobic e. monpolar and hydrophilic b.polar and hydrophobie d. polar and...
Week 14- Chapter 21 Homework Problem 21.72 < 52 of 58 Review Constants| Periodic Table Part A How does a point mutation for an enzyme affect the order of amino acids in that protein? Drag the term...
Week 14- Chapter 21 Homework Problem 21.72 < 52 of 58 Review Constants| Periodic Table Part A How does a point mutation for an enzyme affect the order of amino acids in that protein? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Reset Help then the order of amino acids will change in the of the polypeptide chain If the resulting codon still codes for the same amino acid, If the...
Question 4 Multi-Part Questions. Make sure to answer ALL parts (a-c)! You have isolated two versions...
Question 4 Multi-Part Questions. Make sure to answer ALL parts (a-c)! You have isolated two versions of the same enzyme, a wild type and mutant. The marteses You have determined the following kinetic characteristics for each of the enzymes. Vmax Wild Type Km 200 umol / min 0.2mm Mutant 2 umol / min 20mm and the reaction is a two-step reaction where k.1 is much larger than k3, which enzyme has the higher affinity for substrate to you You determine...
1. Which of the following statements describes lipids? A) Lipids all have the steroid backbone. B)...
1. Which of the following statements describes lipids? A) Lipids all have the steroid backbone. B) The body stores excess calories as lipids. C) Lipids are insoluble in water, but soluble in nonpolar solvents. D) Lipids are soluble in water, but insoluble in nonpolar solvents. E) Lipids are insoluble in all solvents 2. Which of the following type of molecule is not a lipid? A) amino acid B) triglyceride C) phospholipid D) steroid E) eicosanoid 3. Which type of lipid...
Discussion Questions The structures of acetanilide and malonic acid are provided below 1. For each structure,...
Discussion Questions The structures of acetanilide and malonic acid are provided below 1. For each structure, draw circles around the polar and nonpolar regions of the molecule, and label each circled regiorn with the type of intermolecular attractive force it can use to interact with other molecules. Acetanilide Malonic Acid но CH2 OH 2. Now-thoroughly explain (on the basis of polarity/nonpolarity and intermolecular attractive forces) how the acetanilide was separated from the malonic acid by recrystallization from water. And explain...
1&2 pls 1 of 1 Page 1 1. Consider the following domain diagram of a hypothetical...
1&2 pls
1 of 1 Page 1 1. Consider the following domain diagram of a hypothetical integral membrane protein (black segments regions of nonpolar amino acids). Describe the orientation of this protein in the ER membrane. Where would you expect for find the N and termini? How many transmembrane segments would you predict? + N 2. Consider the partial amino acid sequence of the hypothetical protein shown below. In which cellular compartment would you expect to find the functional protein?...
List and describe the two approaches to determining the tertiary structure of a protein. Experimental Determination...
List and describe the two approaches to determining the tertiary structure of a protein. Experimental Determination Computational prediction There are three methods of computational structure prediction. Define each of the methods and describe when each method would be used. There are three types of helices formed by the secondary structure of protein. List three helices and rate how tightly coiled they are. Explain your reasoning. Choose any three of the twenty amino acids. Based on what you know about the...
1. A catalyst enhances the reaction rate by: a. Adding energy to the reaction b. Increasing...
1. A catalyst enhances the reaction rate by: a. Adding energy to the reaction b. Increasing the activation energy required for the reaction c. Reducing the activation energy required for the reaction d. Improving binding of the product to the active site 2. Numerical answer: During aerobic respiration how many ATP molecules are produced by the oxidation of a single molecule of pyruvate? 3. The trace elements magnesium and zinc, which are required for bacterial growth, are typically used as:...
Please answer as many as you can. Will rate!! Across 4. Type of protein that spans...
Please answer as many as you can. Will
rate!!
Across
4. Type of protein that spans the entire
membrane
5. One of the amino acid residues used to form
O-linked glycoproteins.
7. Newly synthesized phospholipids are
inserted into the _____ side of the smooth ER membrane.
8. Type of bond used to link membrane proteins
to a membrane lipid
10. One of the sugars that can be added to
phosphatidylinositol to make glycosylphosphatidylinosiol
12. Enzyme that joins fatty acids and...
Two Biology problems Please answer all of these with details otherwise please 'do not answer any'...
Two Biology problems
Please answer all of these with details otherwise please 'do not
answer any'
A. The figure above shows two types of carbohydrates commonly found in plants. Which of the following is a correct statement about these carbohydrates? a. A is an energy storage polysaccharide because its beta-glycosidic linkages are more resistant to hydrolysis. b. B is a structural polysaccharide because its beta-glycosidic linkages are more easily hydrolyzed. c. B is an energy storage polysaccharide because its alpha-glycosidic...
7. Hemoglobin, which carries oxygen to the cell, is an example b. storage of what type of protein? d. transport c. hormone a. structural 8. An essential amino acid is an amino acid that a. must be provided in the diet. c. does not exist as a zwitterions. b. is missing from the diet d. is synthesized in the body. 9. This amino acid would be: a nonpolar and hydrophobic e. monpolar and hydrophilic b.polar and hydrophobie d. polar and...
Week 14- Chapter 21 Homework Problem 21.72 < 52 of 58 Review Constants| Periodic Table Part A How does a point mutation for an enzyme affect the order of amino acids in that protein? Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Reset Help then the order of amino acids will change in the of the polypeptide chain If the resulting codon still codes for the same amino acid, If the...
Question 4 Multi-Part Questions. Make sure to answer ALL parts (a-c)! You have isolated two versions of the same enzyme, a wild type and mutant. The marteses You have determined the following kinetic characteristics for each of the enzymes. Vmax Wild Type Km 200 umol / min 0.2mm Mutant 2 umol / min 20mm and the reaction is a two-step reaction where k.1 is much larger than k3, which enzyme has the higher affinity for substrate to you You determine...
Discussion Questions The structures of acetanilide and malonic acid are provided below 1. For each structure, draw circles around the polar and nonpolar regions of the molecule, and label each circled regiorn with the type of intermolecular attractive force it can use to interact with other molecules. Acetanilide Malonic Acid но CH2 OH 2. Now-thoroughly explain (on the basis of polarity/nonpolarity and intermolecular attractive forces) how the acetanilide was separated from the malonic acid by recrystallization from water. And explain...
1&2 pls
1 of 1 Page 1 1. Consider the following domain diagram of a hypothetical integral membrane protein (black segments regions of nonpolar amino acids). Describe the orientation of this protein in the ER membrane. Where would you expect for find the N and termini? How many transmembrane segments would you predict? + N 2. Consider the partial amino acid sequence of the hypothetical protein shown below. In which cellular compartment would you expect to find the functional protein?...
List and describe the two approaches to determining the tertiary structure of a protein. Experimental Determination Computational prediction There are three methods of computational structure prediction. Define each of the methods and describe when each method would be used. There are three types of helices formed by the secondary structure of protein. List three helices and rate how tightly coiled they are. Explain your reasoning. Choose any three of the twenty amino acids. Based on what you know about the...
1. A catalyst enhances the reaction rate by: a. Adding energy to the reaction b. Increasing the activation energy required for the reaction c. Reducing the activation energy required for the reaction d. Improving binding of the product to the active site 2. Numerical answer: During aerobic respiration how many ATP molecules are produced by the oxidation of a single molecule of pyruvate? 3. The trace elements magnesium and zinc, which are required for bacterial growth, are typically used as:...
Please answer as many as you can. Will
rate!!
Across
4. Type of protein that spans the entire
membrane
5. One of the amino acid residues used to form
O-linked glycoproteins.
7. Newly synthesized phospholipids are
inserted into the _____ side of the smooth ER membrane.
8. Type of bond used to link membrane proteins
to a membrane lipid
10. One of the sugars that can be added to
phosphatidylinositol to make glycosylphosphatidylinosiol
12. Enzyme that joins fatty acids and...
Two Biology problems
Please answer all of these with details otherwise please 'do not
answer any'
A. The figure above shows two types of carbohydrates commonly found in plants. Which of the following is a correct statement about these carbohydrates? a. A is an energy storage polysaccharide because its beta-glycosidic linkages are more resistant to hydrolysis. b. B is a structural polysaccharide because its beta-glycosidic linkages are more easily hydrolyzed. c. B is an energy storage polysaccharide because its alpha-glycosidic...
Most questions answered within 3 hours.
-
Rod figures that it takes an average (mean) of =20 minutes with
a standard deviation of...
asked 8 minutes ago -
You have 5 ul of a pure (undiluted) culture at a concentration
of 3.6 x 106...
asked 12 minutes ago -
______ activity indicates the presence of an electron transport
chain.
1- gelatinase 2- oxidase 3- caseinase...
asked 15 minutes ago -
The molarity of a silver nitrate solution is 0.192 M. How many
grams of silver ions...
asked 28 minutes ago -
Which of the following solutes will produce a greater increase
in boiling point when it is...
asked 24 minutes ago -
true or false: Series connected electrical circuit is a voltage
divider, and voltage of each device...
asked 19 minutes ago -
A 100-W lightbulb has a resistance of about 12 Ω when cold (20
∘C) and 128...
asked 23 minutes ago -
For the asset shown in the following table, use the capital
asset pricing model to find...
asked 24 minutes ago -
If the impulse response of a circuit is a pulse y(t) = u(t) –
u(t-T), T...
asked 30 minutes ago -
Eukaryotic cells have __ which is similar to prokaryotes of
Archaea.
A Ester-linked membrane lipids
B...
asked 40 minutes ago -
true or false. If work is done on a system by it's
surroundings, its value is...
asked 44 minutes ago -
Rene Descartes establishes a dualist approach to the world.
Explain this dualism, and how it connects...
asked 50 minutes ago