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Suppose that you take 260 mg of an antibiotic every 8 hr. The half-life of the...
If this drug has a half-life of 8-hr instead of 4-hr, what is the amount of...
If this drug has a half-life of 8-hr instead of 4-hr, what is the amount of drug in the body at 24-hr and 48-hr? time 0 hr 8 hr 16 hr 24 hr 32 hr 40 hr 48 hr drug administered 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg drug remaining 100 mg ? ? ? ? ? ?
(a) If a patient takes a 100 mg dose of a drug A (with half-life of...
(a) If a patient takes a 100 mg dose of a drug A (with half-life of 4 hr) every 4-hr, how much drug would be remain in the body at 24-hr (6 half-lives later)? Show work time 0 4 8 12 16 20 24 dose administered 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg total drug remaining in body 100 mg
An antibiotic has a variable half-life from 2 to 6 h in the general population. A...
An antibiotic has a variable half-life from 2 to 6 h in the general population. A patient was given an IV infusion at a rate of 15 mg/h. Blood samples were taken at 8 and 48 h. Plasma concentrations were 5.5 and 6.5 mg/L respectively. Estimate the half-life of the drug in this patient.
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
A 208 lb hospitalized patient received intermittent intravenous infusions of an antibiotic for a serious and...
A 208 lb hospitalized patient received intermittent intravenous infusions of an antibiotic for a serious and life threatening infection from a burn wound. The patient received 3.3 mg/kg infused over 20 minutes administered every 6 hours. A blood samples was collected 45 minutes before the third infusion was started and the drug concentration was found to be 16.6 mcg/mL. Another blood sample was collected 45 minutes after the third infusion was completed and the drug concentration was found to be...
V Question 5 3.03 pts Suppose a radioactive isotope has a half-life t% = 99.1 hr....
V Question 5 3.03 pts Suppose a radioactive isotope has a half-life t% = 99.1 hr. How long will it take for a sample of the isotope to decay to 3.0% of its original activity? a. 218 hr b. 0.0354hr c. 348 yr d. 297 hr e. 501 hr O a Ob Ос Question 6 3.03 pts A radioactive isotope has a half-life, t% = 27.3 yr How long will it take for a 3.27 mCi sample of this isotope...
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then...
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
A drug has linear pharmacokinetics, an half-life of 6 hours and a volume of distribution of...
A drug has linear pharmacokinetics, an half-life of 6 hours and a volume of distribution of 43L. How long it will take to reach 90% of steady state in a 33 year old patient receiving a 20mg/hr V-infusion? a. 20 hours b. 36 hours Oc. 142 hours Odinot enough information provided
WM is a 23 year old female, who weighs 170 lb, and is on a drug...
WM is a 23 year old female, who weighs 170 lb, and is on a drug administered as a continuous IV infusion. The infusion rate is 29.3 mg/hr and the drug half life is 11.2 hours. The drug has a volume of distribution of 2.7 L/kg. How long will it take for the drug concentration to reach steady state? Note: Please provide your answer in units of hr
16. Suppose that the allergy drug, Sneezebgone, has a half life of 12 hours and is...
16. Suppose that the allergy drug, Sneezebgone, has a half life of 12 hours and is excreted at a rate that is proportional to the amount present. At 8am, Declan takes one 10 mg dose of Sneezebgone, and then another 10mg dose at 8pm. Assuming that the drug is given intravenously via injection and mixed into his bloodstream immediately) how many mg of sneezebgone are in his system at midnight?
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
A 208 lb hospitalized patient received intermittent intravenous infusions of an antibiotic for a serious and life threatening infection from a burn wound. The patient received 3.3 mg/kg infused over 20 minutes administered every 6 hours. A blood samples was collected 45 minutes before the third infusion was started and the drug concentration was found to be 16.6 mcg/mL. Another blood sample was collected 45 minutes after the third infusion was completed and the drug concentration was found to be...
V Question 5 3.03 pts Suppose a radioactive isotope has a half-life t% = 99.1 hr. How long will it take for a sample of the isotope to decay to 3.0% of its original activity? a. 218 hr b. 0.0354hr c. 348 yr d. 297 hr e. 501 hr O a Ob Ос Question 6 3.03 pts A radioactive isotope has a half-life, t% = 27.3 yr How long will it take for a 3.27 mCi sample of this isotope...
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
A drug has linear pharmacokinetics, an half-life of 6 hours and a volume of distribution of 43L. How long it will take to reach 90% of steady state in a 33 year old patient receiving a 20mg/hr V-infusion? a. 20 hours b. 36 hours Oc. 142 hours Odinot enough information provided
WM is a 23 year old female, who weighs 170 lb, and is on a drug administered as a continuous IV infusion. The infusion rate is 29.3 mg/hr and the drug half life is 11.2 hours. The drug has a volume of distribution of 2.7 L/kg. How long will it take for the drug concentration to reach steady state? Note: Please provide your answer in units of hr
16. Suppose that the allergy drug, Sneezebgone, has a half life of 12 hours and is excreted at a rate that is proportional to the amount present. At 8am, Declan takes one 10 mg dose of Sneezebgone, and then another 10mg dose at 8pm. Assuming that the drug is given intravenously via injection and mixed into his bloodstream immediately) how many mg of sneezebgone are in his system at midnight?
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