Question

Which of the following is the LEAST likely direct consequence of a substitution mutation?

	creating a non-functional version of a protein
	creating a new version of a protein
	creating a new amino acid in the universal genetic code
	creating a different codon in a gene
	creating a new allele of a gene

Answer 1

The consequence of substitution mutation which is LEAST likely to occur directly is CREATING A NEW ALLELE OF A GENE.

This is because by substitution mutation can cause the formation of a non functional version of a protein, in caser the substitution leads to the formation of stop codons, the protein syhnthesis will stop.

A new version of protein can also be formed, for example in Sickle cell Anaemia, Glutamic acid is changed to Valine, by substitution at a single base.

New amino acid formation in the genetic code is also possible as well as different codon can be formed, but a new allele can not be generated because the allele are identical copies of a gene having same contrasting characters, which cannot be formed by a base substitution mutation