Question

1. How would binding to the minor groove of DNA affect the number of possible sequences recognized?

2. In some proteins promoters or repressors there are two helix turn helix DNA binding motifs, how could this increase the number of unique sequences that it could bind to? (Hint: not just a doubling)

Please answer both questions in detail. I am having a difficult time understanding both questions. Thank You!

Answer 1

Its Мај61 Hoove grooves A groove The major groves in DNA provide binding space for larger proteins, as here the backbones are får appert , leading to mere no. of þessible sequences to be recognized While, Minor grooves in DNA provide smaller Space for the binding of smaller proteins, coz the backbones of DNA are close together, leading to less no col possible sequences to be recognized Du the DNA. 2. Aus aus. Turn- @ helin a Jo Es DNA binding motif & 8-Turn It Turn DNA binding motif @ Helin In Helix-tuyn helix - the 2 6 alpha helices, et N-terminal end & C-terminal end act as DNA binding motif.. The increased no. of helices provide more flexibility to protein, leading to increascal no. of unique sequences binding by DNA binding molife of Helix-turu-helix.