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Describe two outcomes of complement activation Why are complement proteins made in an inactive form?

Describe two outcomes of complement activation

Why are complement proteins made in an inactive form?

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Answer #1

Complement activation has various outcomes, two of them are :

Cell lysis:

The primary function of complement activation is to lyse the microbes that have invaded the host.

Inflammation:

During complement activation, some of the complement components are split into fragments, the larger fragments continue the complement cascade, whereas the smaller fragments play important roles in inflammation.

The complement proteins are made in an inactive form and get activated when triggered, like when a microbe attacks the host body. If these proteins are always active then they might end up destroying/ phagocytizing the normal host cells even when they pose no danger to the organism.

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