Will an insertion or a deletion of three nucleotides result in a frameshift mutation? Explain why or why not.
Insertion or deletion of single base pairs (or more, except multiples of three) in DNA results in frame shift mutations, in this; the reading frame shifts at the point of mutation and results in non-functional proteins.
Insertion or a deletion of three nucleotides result in a frameshift mutation does not result in frameshift mutation because it exactly removes one codon or inserts one codon, so the change in the resulting mRNA is limited to one particular amino acid, but the remaining sequence remain the same.
Will an insertion or a deletion of three nucleotides result in a frameshift mutation? Explain why...
Why is an insertion or deletion more likely to result in a damaging mutation than a point mutation? 1.Point mutations only change two or three nucleotides 2.Point mutations never change the amino acid that is called for in the protein 3.Insertions/deletions change all codons that follow them, unless they are indels of 3, 6, 9, etc 4.Point mutations cannot result in a stop codon, whereas insertions and deletions can.
What type of mutation in HBB produces HgbS? [2 pt] substitution frameshift insertion deletion
11. Match each type of mutation with the corresponding description. (4 points) Missense An insertion or deletion of nucleotides that are not in multiples of 3. Nonsense A mutation that does not alter the protein sequence. Silent A mutation that confers an amino acid substitution. Frameshift A mutation that confers a premature stop codon.
Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion, Frameshift mutation Label these genetic changes (a-e). More than one answer may apply to each answer. a. GC->CG in the protein coding region on a gene. b. GC->TA in a GAA glutamate codon c. Loss of three bases GAA for a glutamate codon d. GC->CG in a tRNA gene e. GC->AT in the ribosome binding site of a mRNA
QUESTION 3 In a "frameshift" mutation O a the mutation is not in DNA. the nucleotide that mutates causes a stop codon to occur instead of the placement of an amino acid. c. addition or deletion of one or two nucleotides causes the codons to be off pattern and therefore the mutation. 4. the nucleotide that mutates causes no change in the amino acid specified.
What type of mutation will result in the production of the regular protein? neutral substitution deletion frameshift
5'-ATG-TCC-TCG-AAT-TTT-CCC-3' if a student induces a 2-nucleotide deletion to this sequence resulting in a frameshift mutation, changing the 3rd through 5th amino acids to Glu Phe Ser, what two nucleotides were deleted?
16. There is a mutation causing an insertion in the above sequence indicated by the underlined nucleotide. 5'-AAGCCATGGGCACTGGAGGTCGGATGAAACATG3'. What kind of mutation is this? a. Silent b. Missense c. Nonsense d. Frameshift e. Deletion
Why might the insertion or deletion of three base pairs in a gene be less harmful than the insertion or deletion of only one or two base pairs?
In E. coli translation of genes that contain a frameshift mutation often result in a truncated protein. This is because the frameshift mutation often result in a nonsense codon downstream in the DNA sequence. Can you come up with a reason why nonsense mutations are so prevalent after a shift in reading frame in an E. coli DNA sequence?