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In dog skeletal muscle, the extracellular and intracellular concentration of Na+ are 150 mM and 12...

In dog skeletal muscle, the extracellular and intracellular concentration of Na+ are 150 mM and 12 mM, and those of K+ are 2.7 mM and 140 mM, respectively. Calculate the total free energy change as 3 Na+ are transported out and 2 K+ are transported in by the Na+-K+ pump. Assume that the temperature is 25°C and the membrane potential is –60 mV. Give your answer in kJ/mol to 1 decimal place.

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Answer #1

The free energy change for the transport of three sodium ion out of the cell is +1.5 KJ / mole.

The  free energy change required for 3 Na+ transported out = RT In (Co/Ci)zFE

= 3 x 0.0474= 1.41kj/mole

The free energy change for the transport of two Potassium ion into the cell is +31.2 kJ / mol

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