In dog skeletal muscle, the extracellular and intracellular concentration of Na+ are 150 mM and 12 mM, and those of K+ are 2.7 mM and 140 mM, respectively. Calculate the total free energy change as 3 Na+ are transported out and 2 K+ are transported in by the Na+-K+ pump. Assume that the temperature is 25°C and the membrane potential is –60 mV. Give your answer in kJ/mol to 1 decimal place.
The free energy change for the transport of three sodium ion out of the cell is +1.5 KJ / mole.
The free energy change required for 3 Na+ transported out = RT In (Co/Ci)zFE
= 3 x 0.0474= 1.41kj/mole
The free energy change for the transport of two Potassium ion into the cell is +31.2 kJ / mol
In dog skeletal muscle, the extracellular and intracellular concentration of Na+ are 150 mM and 12...
1. Animal cells have a Na,K pump that couples the energy of ATP hydrolysis to transport 3 Na ions out of the cell and 2 K ions into the cell. Inside astrocytes, the concentration of Na is 20 mM and the concentration of K is 130 mM. The extracellular concentrations of Na and K are 145 mM and 5 mM, respectively. Calculate the energy required for the transport of Na and K , with this stoichiometry; assume that the cell...
Extra Problem for Chapter 9 1. The ion concentrations in the table are representative of those found in mammalian skeletal muscle at 37°C. The resting membrane potential for the skeletal muscle cell is approximately.90 mv. A) Calculate the Nernst potentials for each ion and enter the calculated values in the table. Be sure to show calculations. lon Intracellular Concentration (MM) Extracellular Concentration (MM) Nernst (equilibrium) Potential (mv) 150 145 1.5 120
1. If the membrane potential of sodium ions in a cell is equal to +60 mV, what is its membrane potential for chloride ions if they are found in the exact same concentrations as sodium? Give your answer in mV. 2. Given a cell membrane with the following parameters- Ion Extracellular concentration (mmol/L) Intracellular concentration (mmol/L) Permeability K+ 10 150 1 Na+ 140 15 0.04 Cl- 100 7 0.45 calculate the membrane potential of the cell in mV. (Round your...
please show the work. thanks What is the free energy change for the transport of calcium ions into a cell. The intracellular [Ca2+] is 1 mM and extracellular [Ca2+] is 1 uM. Assume a membrane potential of -100 mV and T-25°C. Give your answer in kJ/mol to one decimal place.
According to biophysics As a result of an experiment following measurements were obtained from a cell: intracellular Na* concentration of 10 mm, intracellular K* concentration of 140 mm, intracellular Cl' concentration of 5 mm, interstitial Na* concentration of 150 mm, interstitial K concentration of 5 mm, interstitial Cl' concentration of 120 mm, relative potassium/sodium permeability of 32. Using these values calculate membrane potential of these cells. (RT/F = 26.7 mV, 37°C) (5 pts). Select one: a. -71 mV b. +71...
1.) If the intracellular chloride ion concentration of a cell is 9 mM and has an extracellular concentration of 125 mM, then the equilibrium potential for chloride ion is ___ mV. (round to the nearest 10th decimal place) 2.) Typically found at the apical surface of an epithelial layer, a __ __ serves to prevent/limit paracellular transport as well as sealing and providing support to the epithelium. 3.) In order for a cell to respond to a regulatory molecule, it...
please write thorough answers thanks PART 1 Answer ONLY ONE of the following TWO questions of Part 1 ie a) OR b) a) A typical, healthy nerve cell in the body has intracellular and extracellular Na, K and Cl' concentrations as shown below. Na concentration: Extracellular: = 150 mm K concentration: Extracellular: = 4 mm Ci concentration: Extracellular: = 100 mm Temperature = 37°C (303.3K) R (the Universal Gas constant) = 8.315 VCmol'k F (Faraday's constant) = 96,485 Cmol Intracellular:...
The transport of Na+ ions across a membrane, from a region where the concentration is 1 μM to a region where it is 100 μM, is coupled to the hydrolysis of ATP. Transport is opposed by a membrane potential of 70 mV. Assuming energy coupling is 100% efficient, the hydrolysis of 1 mole of ATP can drive the transport of how many moles of Na+ at 37˚C if the ΔG for ATP hydrolysis is -53.4 kJ/mol under intracellular conditions?
(1) Mitochondria regulate the concentration of calcium ions in the cytoplasm, by allowing the ions to equilibrate across the mitochondrial membrane. If the mitochondrion has a membrane potential of –150 mV relative to the cytoplasm, and the cytoplasmic concentration of Ca2+ is 1 μM, what is the mitochondrial Ca2+ concentration? Assume a temperature of 37 C. (2) The membrane calcium pump of the malarial parasite Trypanosoma cruzipumps out calcium ions from the parasite cell interior, hydrolyzing one molecule of ATP...
Given these parameters, what is the AG for K ion transport into the frog muscle cell in the presence of Ach? Dr. Knowsalot smiles and nods. "Good," she says. "Now let's see whether K+ ions pass through the open Ach receptors into the cell. As you might remember, these channels are permeable to Na+, K+, and Ca2+. For a typical frog muscle cell, the concentration of K+ is roughly 124 mM inside the cell and 2.30 mM outside the cell."...