Pyruvate dehydrogenase (PDH) deficiency:
What are the biochemical consequences of the enzyme
deficiency?
What are it's downstream and/or upstream metabolic effects?
Pyruvate dehydrogenase (PDH) deficiency: What are the biochemical consequences of the enzyme deficiency? What are it's...
please help, thank you! Which of the following are true of lipoamide in pyruvate dehydrogenase (PDH)? (Choose all that apply.) Select all that apply The "active" part of the chemical structure of lipoamide that participates in the reactions of PDH is an amide group. Lipoamide is reduced by FADH2 from the E1 subunit. Lipoamide accepts an activated aldehyde from TPP in E1. A covalent bond is formed and broken between lipoamide and a compound with three carbon atoms during the...
Identify the statements that accurately describe the structure of the pyruvate dehydrogenase (PDH) complex. Select all that apply. A regulatory kinase and phosphatase are part of the mammalian PDH complex. Several copies each fo E_1 and E_3 surround E_2. E_2 contains three domains. The complex contains multiplex is made up of several copies of E_1.
Why does acetyl CoA, a product of fatty acid catabolism, influence the pyruvate dehydrogenase complex (PDH), a control point in carbohydrate catabolism? When fatty acid breakdown is high, ADP is low and PDH is inhibited by phosphatase activity. When fatty acid breakdown is inhibited, PDH is inhibited by acetyl CoA due to phosphatase activity. When fatty acid breakdown is high, NADH levels drop, causing an increase in E2 activity. When fatty acid breakdown is high, PDH is inhibited by acetyl...
A boy has an impairment in the enzyme pyruvate dehydrogenase. What will be the amount of energy that can be produced in the oxidation of dextrin, a trisaccharide, in the liver of the boy?
What function do the lipolysyl moieties of the second enzyme in the pyruvate dehydrogenase complex serve?
Identify the statements that accurately describe the structure of the pyruvate dehydrogenase (PDH) complex. Select all that apply. E2 contains three functionally distinct domains. A regulatory kinase and phosphatase are part of the mammalian PDH complex. The complex contains multiple copies of E2 and single copies of several other enzymes. several copies each of El and E3 Surround-2. The core of the complex is made up of several copies of E2 Identify the statements that accurately describe the structure of...
3. Describe the role of vitamins in TCA cycle. How will patients having pyruvate dehydrogenase deficiency present clinically?
I1. Mammals lack the enzyme a. Lactate dehydrogenase b. Pyruvate kinase Alcohol Dehydrogenase c. d. Pyruvate decarboxylase None of the above are correct e. 12. The first reaction of the Krebs cycle combines Oxaloacetate and Acetyl CoA to make Citrate b. a. Malate and NADH to make Citrate a-ketoglutarate and citrate to make CO2 d. c- Succinate and Citrate to make Oxaloacetate 13. The electrons held by NADH and FADH, are donated to the which complexes in the ETC respectively?...
The step in metabolism that converts pyruvate to acetyl-CoA involves pyruvate dehydrogenase complex is shown. NADH NAD Correm A CEO CH co G Pyruvate AwA What is true about this step? ATP is required but not shown The enzyme is a multi-enzyme complex involving TPP. It requires O2 It is an easily reversible reaction
ES 4) The enzyme pyruvate dehydrogenase binds arvate. CH.COYCOO is ctive Which amino acid is most likely to be present at the active site of pyruvate scher A) Aspartate B) Glutamate C) Phenylalanine D) Lysine E) Valine