7. Consider the reactions below and their given standard free-energy changes. Phosphocreatine ↔ creatine + P...
7. Consider the reactions below and their given standard free-energy changes.
Phosphocreatine ↔ creatine + P i Δ G' ° = –43.0 kJ/mol
ATP ↔ ADP + P i Δ G' ° = –30.5 kJ/mol
A) What is the overall Δ G' ° for the following reaction? Phosphocreatine + ADP ↔ creatine + ATP
B) Explain how phosphocreatine can be used as a kind of mechanism to STORE excess ATP during periods of rest. Why might this be necessary?
Homework Answers
- Phosphocreatine can be used as a kind of mechanism to store excess ATP. From the above reaction, Gibbs free energy for the net reaction turned out to be negative which implies that the reaction occurs spontaneously in nature. Free ATP in the muscle is hydrolysed in the muscle releasing an ADP molecule and inorganic phosphate. This inorganic phosphate released is taken up by the creatine to form phosphocreatine. Since this free ATP is used quickly in the muscle, the need to regenerate ATP is essential for the activity of muscle. This regeneration of ATP requires the transfer of high energy phosphate from phosphocreatine to ADP. Thus this reaction permits the rephosphorylation of ADP to ATP which is the immediate source of energy in muscle contraction and hence is necessary.
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7. Consider the reactions below and their given standard
free-energy changes.
Phosphocreatine ↔ creatine + P...
Given the following: phosphocreatine → creatine + Pi ΔG = −43.0 kJ/mol ATP → ADP + Pi...
Given the following: phosphocreatine → creatine + Pi ΔG = −43.0 kJ/mol ATP → ADP + Pi ΔG = −30.5 kJ/mol What is the overall ΔG for the following Reaction? phosphocreatine + ADP → creatine + ATP A) -12.5 kJ/mol B) + 73.5 kJ/mol C) -73.5 kJ/mol D) + 12.5 kJ/mol
Consider the following reactions: #1: ATP + H2O -> ADP +P, #2: Phosphocreatine + H20 —...
Consider the following reactions: #1: ATP + H2O -> ADP +P, #2: Phosphocreatine + H20 — #3: Phosphocreatine + ADP — creatine + P creatine + ATP (AG" =-31 kJ/mol) (4Gº = -43 kJ/mol) (AG'= -12 klimol) AG" for reaction #3 would be 12 km 0-12 kJimo 0 -43 kJimo 0 74 klimo
2. Hydrolysis of 0.5 M studentose catalyzed by teacherase to become successose is 95% complete at...
2. Hydrolysis of 0.5 M studentose catalyzed by teacherase to become successose is 95% complete at equilibrium (i.e., only 5% of the studentose remains). What is AG"? (R = 8.315 J/mol K; T = 298 K) 3. The standard free-energy changes for the reactions below are given. Phosphocreatine creatine + Pi AG"=-43.0 kJ/mol ATP → ADP + Pi AG" = -30.5 kJ/mol The overall AG" for the reaction: Phosphocreatine + ADP creatine + ATP, is _ A) -73.5 kJ/mol C)...
2. For the following reaction: ATP+ creatine + H2O creatine phosphate + ADP + P, The...
2. For the following reaction: ATP+ creatine + H2O creatine phosphate + ADP + P, The relevant half reactions are: ATP → ADP + Pi Creatine phosphate + H2O-> creatine AG-30.5 kJ/mol ΔG°,--43.1 kJ/mol a. (2 pts.) Calculate the ΔG°, for the overall reaction. b. (2 pts.) Is the reaction spontaneous or non-spontaneous? Endergonic or exergonic?
To answer this question, please reference the Problem Solving Video: Free Energy, ATP, and Creatine in...
To answer this question, please reference the Problem Solving Video: Free Energy, ATP, and Creatine in Resting Muscles. The standard free energy, AGⓇ', value for an enzymatic reaction with several al components is the sum of the AGⓇ values for each component. Creatine kinase catalyzes the transfer of a phosphate group from creatine phosphate to ADP to form ATP. Standard Free Energy of Hydrolysis Standard E Compound kJ.mol-1 creatine phosphate -43.1 ATP (to ADP) -30.5 creatine phosphate +H,0 creatine +...
To answer this question, please reference the Problem Solving Video: Free Energy, ATP, and Creatine in...
To answer this question, please reference the Problem Solving Video: Free Energy, ATP, and Creatine in Resting Muscles. The standard free energy ( Δ G ∘ ′ ) of the creatine kinase reaction is − 12.6 kJ ⋅ mol − 1 . The Δ G value of an in vitro creatine kinase reaction is − 0.1 kJ ⋅ mol − 1 . At the start of the reaction, the concentration of ATP is 6 mM, the concentration of creatine is...
1) SHOW WORK 12. During glycolysis, glucose 1-phosphate is converted to fructose 6-phosphate in two successive...
1) SHOW WORK
12. During glycolysis, glucose 1-phosphate is converted to fructose 6-phosphate in two successive reactions: glucose 1-phosphate → glucose 6-phosphate glucose 6-phosphate + fructose 6-phosphate AG'' = -7.1 kJ/mol AG'º = +1.7 kJ/mol 13. The standard free-energy changes for the reactions below are given. phosphocreatine → creatine + Pi ATP → ADP + Pi AG" = 43.0 kJ/mol AG" = -30.5 kJ/mol What is the overall AG' for the following reaction? Iw a dee Hydrolysis of 1 M...
4. Consider the following reaction: ATP + pyruvate phosphoenolpyruvate + ADP Given: Standard free energy of...
4. Consider the following reaction: ATP + pyruvate phosphoenolpyruvate + ADP Given: Standard free energy of hydrolysis for ATP to ADP is -30.5 kJ/mol Standard free energy of hydrolysis for phosphenolpyruvate to pyruvate is -61.9 kJ/mol Calculate AGⓇ and Key for this reaction.
stion 8 of 25 > The table lists the standard free energies of hydrolysis (AGⓇ) of...
stion 8 of 25 > The table lists the standard free energies of hydrolysis (AGⓇ) of some phosphorylated compounds. Compound kJ mol kcal mol-1 Phosphoenolpyruvate (PEP) -61.9 --14.8 1,3-Bisphosphoglycerate (1,3-BPG) -49.4 - 11.8 Creatine phosphate -43.1 ATP (to ADP) -30.5 -7.3 Glucose 1-phosphate -20.9 -5.0 Pyrophosphate (PP) Glucose 6-phosphate Glycerol 3-phosphate -9.2 -2.2 10.3 -4.6 -13.8 3.3 What is the direction of each of the following reactions when the reactants are initially present in equimolar amounts? The reaction ATP+H,O -...
please help! thanks TABLE 12-4 Standard Free Energy Change for Phosphate Hydrolysis Compound AGⓇ' (kJ. mol-')...
please help! thanks
TABLE 12-4 Standard Free Energy Change for Phosphate Hydrolysis Compound AGⓇ' (kJ. mol-') Phosphoenolpyruvate -61.9 1,3-Bisphosphoglycerate -49.4 ATP → AMP + PP, -45.6 Phosphocreatine -43.1 ATP ADP + P -30.5 Glucose-1-phosphate -20.9 PP, 2P, -19.2 Glucose-6-phosphate -13.8 Glycerol-3-phosphate -9.2 thioester bond AGⓇ' = -31.5 kJ•mol-1 H20 O CH3 -C-s-CoA I CH3 -C-0- + COA-SH Acetyl-CoA The formation of acetyl CoA from acetate is an ATP driven reaction: Acetate + ATP + COA <--> acetyl COA + AMP...
Consider the following reactions: #1: ATP + H2O -> ADP +P, #2: Phosphocreatine + H20 — #3: Phosphocreatine + ADP — creatine + P creatine + ATP (AG" =-31 kJ/mol) (4Gº = -43 kJ/mol) (AG'= -12 klimol) AG" for reaction #3 would be 12 km 0-12 kJimo 0 -43 kJimo 0 74 klimo
2. Hydrolysis of 0.5 M studentose catalyzed by teacherase to become successose is 95% complete at equilibrium (i.e., only 5% of the studentose remains). What is AG"? (R = 8.315 J/mol K; T = 298 K) 3. The standard free-energy changes for the reactions below are given. Phosphocreatine creatine + Pi AG"=-43.0 kJ/mol ATP → ADP + Pi AG" = -30.5 kJ/mol The overall AG" for the reaction: Phosphocreatine + ADP creatine + ATP, is _ A) -73.5 kJ/mol C)...
2. For the following reaction: ATP+ creatine + H2O creatine phosphate + ADP + P, The relevant half reactions are: ATP → ADP + Pi Creatine phosphate + H2O-> creatine AG-30.5 kJ/mol ΔG°,--43.1 kJ/mol a. (2 pts.) Calculate the ΔG°, for the overall reaction. b. (2 pts.) Is the reaction spontaneous or non-spontaneous? Endergonic or exergonic?
To answer this question, please reference the Problem Solving Video: Free Energy, ATP, and Creatine in Resting Muscles. The standard free energy, AGⓇ', value for an enzymatic reaction with several al components is the sum of the AGⓇ values for each component. Creatine kinase catalyzes the transfer of a phosphate group from creatine phosphate to ADP to form ATP. Standard Free Energy of Hydrolysis Standard E Compound kJ.mol-1 creatine phosphate -43.1 ATP (to ADP) -30.5 creatine phosphate +H,0 creatine +...
1) SHOW WORK
12. During glycolysis, glucose 1-phosphate is converted to fructose 6-phosphate in two successive reactions: glucose 1-phosphate → glucose 6-phosphate glucose 6-phosphate + fructose 6-phosphate AG'' = -7.1 kJ/mol AG'º = +1.7 kJ/mol 13. The standard free-energy changes for the reactions below are given. phosphocreatine → creatine + Pi ATP → ADP + Pi AG" = 43.0 kJ/mol AG" = -30.5 kJ/mol What is the overall AG' for the following reaction? Iw a dee Hydrolysis of 1 M...
4. Consider the following reaction: ATP + pyruvate phosphoenolpyruvate + ADP Given: Standard free energy of hydrolysis for ATP to ADP is -30.5 kJ/mol Standard free energy of hydrolysis for phosphenolpyruvate to pyruvate is -61.9 kJ/mol Calculate AGⓇ and Key for this reaction.
stion 8 of 25 > The table lists the standard free energies of hydrolysis (AGⓇ) of some phosphorylated compounds. Compound kJ mol kcal mol-1 Phosphoenolpyruvate (PEP) -61.9 --14.8 1,3-Bisphosphoglycerate (1,3-BPG) -49.4 - 11.8 Creatine phosphate -43.1 ATP (to ADP) -30.5 -7.3 Glucose 1-phosphate -20.9 -5.0 Pyrophosphate (PP) Glucose 6-phosphate Glycerol 3-phosphate -9.2 -2.2 10.3 -4.6 -13.8 3.3 What is the direction of each of the following reactions when the reactants are initially present in equimolar amounts? The reaction ATP+H,O -...
please help! thanks
TABLE 12-4 Standard Free Energy Change for Phosphate Hydrolysis Compound AGⓇ' (kJ. mol-') Phosphoenolpyruvate -61.9 1,3-Bisphosphoglycerate -49.4 ATP → AMP + PP, -45.6 Phosphocreatine -43.1 ATP ADP + P -30.5 Glucose-1-phosphate -20.9 PP, 2P, -19.2 Glucose-6-phosphate -13.8 Glycerol-3-phosphate -9.2 thioester bond AGⓇ' = -31.5 kJ•mol-1 H20 O CH3 -C-s-CoA I CH3 -C-0- + COA-SH Acetyl-CoA The formation of acetyl CoA from acetate is an ATP driven reaction: Acetate + ATP + COA <--> acetyl COA + AMP...
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