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               Which mutation would probably be the most deleterious? A missense mutation in the second codon...

               Which mutation would probably be the most deleterious?

  1. A missense mutation in the second codon
  2. A frame-shift mutation in the second codon
  3. A nonsense mutation in the last codon
  4. A silent mutation in the second codon
  5. A missense mutation in the last codon
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Answer #1

option b

Base substitutions cause relatively minor mutations, like missense, nonsense, and silent mutations. But, insertions and deletions cause a change in the length of a gene, which causes a shift in the codon reading frame. Frameshift mutation includes both insertion and deletion.

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