Explain how Rett syndrome is both genetic and epigenetic?
Explain how Rett syndrome is both genetic and epigenetic?
Homework Answers
Rett syndrome is genetic as it involves the X-linked MECP2 gene mutations that is said to be responsible for this neurological syndrome. It is epigenetic in the way as the MECP2 with its diverse function of being a transcription repressor or transcription activator plays a role mostly in epigenetic regulation of target gene expression in Rett syndrome.
That individuals with Down Syndrome (caused by a triplet of genes at chromosome 21, Trisomy 4. It...
that individuals with Down Syndrome (caused by a triplet of genes at chromosome 21, Trisomy 4. It is seen 21) have a shortened life span. Some of this may be due to cardiovascular defects present in about 80% of individuals. A more modern theory is that the cell cycle of individuals with this condition is cycling faster than individuals without the condition. As such, Down Syndrome patients may have an accelerated epigenetic clock. Describe at least three biochemical/genetic/epigenetic factors that...
How do epigenetic traits differ from traditional genetic traits, such as the differences in color and...
How do epigenetic traits differ from traditional genetic traits, such as the differences in color and shape of peas that Mendel studied? A) Phenotype is stably inherited by offspring. B) Phenotype is not transmitted to offspring. C) New phenotype involves changes to the DNA sequence. D) New phenotype is caused by modifications to chromatin. E) Phenotype can be influenced by environmental factors.
How can a dominant lethal mutation (such as that for Rest Syndrome) be transmitted to future generations? - Rett syndrome caused by mutations in the gene that encodes MeCP2 and is X-linked
How can a dominant lethal mutation (such as that for Rest Syndrome) be transmitted to future generations? - Rett syndrome caused by mutations in the gene that encodes MeCP2 and is X-linked
Define and explain the concept of epigenetic regulation. Describe as many mechanisms of epigenetic influence of...
Define and explain the concept of epigenetic regulation. Describe as many mechanisms of epigenetic influence of gene expression as you can and how this information can be retained through cell division and in some cases, passed along accurately to the progeny. Include a discussion of the three types of histone tail editing enzymes and the effect of the dysfunctions of these modifying enzymes. Explain the role of one of these enzymes in GTPTS (OMIM 606170).Note: Open a new browser window...
Genetic ill health like down syndrome or cri du chat syndrome is due ______
Genetic ill health like down syndrome or cri du chat syndrome is due ______
1. What is epigenetics? 2. Epigenetic marks can be influenced by the environment both in utero...
1. What is epigenetics? 2. Epigenetic marks can be influenced by the environment both in utero and by "transgenerational inheritance". How does this happen? 3. Are epigenetic marks reversible? If so, how?
1.Knowing the various genetic and epigenetic changes that occur during multi-step tumorigenesis, which of these would...
1.Knowing the various genetic and epigenetic changes that occur during multi-step tumorigenesis, which of these would you say are likely to be readily uncovered and which may be difficult to be identify? Describe the reasons for these assignments.
Possible genetic modifications that can cause epigenetic changes in gene expression include: (Select all that apply)...
Possible genetic modifications that can cause epigenetic changes in gene expression include: (Select all that apply) DNA methylation chromosomal inversion. chromatin remodeling. histone acetylation. genomic imprinting. mRNA degradation. histone variant localization
Can someone explain this process that occurs in Rett syndrome in this picture below? Not too...
Can someone explain this process that occurs in Rett syndrome in this picture below? Not too sure what CpG island is as well. Thanks! HDACs Corepresso MeCP2 Target gene Transcription CH CH CH CH, CH gat dgdgdgdg data Source: Seo et al., 2014 Clin Psychopharmacol Neurosc 2014-1294-110 Cin Psychopharmacol Neuroki CpG Island
Genetic QUESTIONS FOR RESEARCH AND DISCUSSION 1. Discuss how incomplete penetrance, variable expressivity, pleiotropy, and genetic...
Genetic QUESTIONS FOR RESEARCH AND DISCUSSION 1. Discuss how incomplete penetrance, variable expressivity, pleiotropy, and genetic heterogeneity can affect the severity of a disease in a family. 2. A person can lower risk of preventable types of cardiovascular disease by exercising regularly and following a diet low in saturated fats and simple carbohydrates and high in fruits and vegetables. Why are these approaches ineffective against long QT syndrome? 3. Explain how the molecular bases of the various forms of long...
that individuals with Down Syndrome (caused by a triplet of genes at chromosome 21, Trisomy 4. It is seen 21) have a shortened life span. Some of this may be due to cardiovascular defects present in about 80% of individuals. A more modern theory is that the cell cycle of individuals with this condition is cycling faster than individuals without the condition. As such, Down Syndrome patients may have an accelerated epigenetic clock. Describe at least three biochemical/genetic/epigenetic factors that...
1. What is epigenetics? 2. Epigenetic marks can be influenced by the environment both in utero and by "transgenerational inheritance". How does this happen? 3. Are epigenetic marks reversible? If so, how?
Possible genetic modifications that can cause epigenetic changes in gene expression include: (Select all that apply) DNA methylation chromosomal inversion. chromatin remodeling. histone acetylation. genomic imprinting. mRNA degradation. histone variant localization
Can someone explain this process that occurs in Rett syndrome in this picture below? Not too sure what CpG island is as well. Thanks! HDACs Corepresso MeCP2 Target gene Transcription CH CH CH CH, CH gat dgdgdgdg data Source: Seo et al., 2014 Clin Psychopharmacol Neurosc 2014-1294-110 Cin Psychopharmacol Neuroki CpG Island
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