A) Explain why a base substitution may sometimes also be classified as a missense mutation, but...
A) Explain why a base substitution may sometimes also be classified as a missense mutation, but not always.
B) Where does "mutagenesis" fit into "Genetic Analysis"?
Homework Answers
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A) Explain why a base substitution may sometimes also be
classified as a missense mutation, but...
Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion,...
Using these types of genetic changes: Base substitution, Transition, Transversion, Missense mutation, Nonsense mutation, Insertion, Deletion, Frameshift mutation Label these genetic changes (a-e). More than one answer may apply to each answer. a. GC->CG in the protein coding region on a gene. b. GC->TA in a GAA glutamate codon c. Loss of three bases GAA for a glutamate codon d. GC->CG in a tRNA gene e. GC->AT in the ribosome binding site of a mRNA
Please explain why,, for the second prob, why is it not missense mutation.. 20. The following...
Please explain why,,
for the second prob, why is it not missense mutation..
20. The following bit of the human RefSeq includes the entire first exon of a protein coding gene and part of the second exon 5'-AACTAACCACTGTCCGTACTCTGCCAGCCATCCGTAGC-3' 21. The canonical splice junctions are 5'-GU....AG-3', where ... indicates additional intronic sequence. Which of the following is a candidate for the protein-coding portion of the processed mRNA from this sequence? a. 5'-TACCGACCGTCTACCAATAAC-3' b. 5'-GCTACGGATGGCTGGCAGAGT-3' c. 5' -GUACGGACAGUGGUUAGUUCC-3' d. 5'-AUGGCUGGCAGAUGGUUAGUU-3' e. 5'-AACTAACCATCTGCCAGCCAT-3'...
A substitution mutation is one in which one nucleotide base is changed to another
2. A substitution mutation is one in which one nucleotide base is changed to another Suggest ONE substitution A G mutation in the DNA that would cause the first amino acid in the "# of Eyes" gene to change from alanine (Ala) to valine (Val). In the table below, write the original.3. There is a substitution mutation in the gene for Fangs in which the first DNA base changes from guanine to thymine. The mutation results in a genetic disorder...
Mutations Worksheet-Dcletlon, Inserilon & Substitution
Mutations Worksheet-Dcletlon, Inserilon & SubstitutionThere are several types of mutations:> DELETION (a base is lost/deleted)> INSERTION (an extra base is added/inserted)- Deletion\& insertion may cause what's called a FRAMESHIFT mutation, meaning the reading "frame"changes, thus changing the amino acid sequence from this point forward > SUBSTITUTION (one base is substituted for another)- If a substitution changes the amino acid, it's called a MISSENSE mutation- If a substitution does not change the amino add, it's called a SILENT mutation- If a...
A single mutation has occurred in the following DNA sequence. 5' ATG TTG GCC CAT 3'...
A single mutation has occurred in the following DNA sequence. 5' ATG TTG GCC CAT 3' wild-type (normal) sequence 5' ATG TTG CCC CAT 3' mutant sequence (a) Identify and classify the mutation according to its molecular structure (i.e., insertion, deletion base substitution (transversion), or base substitution (transition)). Briefly explain why you selected this classification. (1.75 marks) (b) Identify and classify the mutation according to its functional effects (i.e., frameshift, missense, nonsense, or silent). Briefly explain why you...
Can a base-pair substitution mutation in a proto-oncogene lead to the production of an oncogene if...
Can a base-pair substitution mutation in a proto-oncogene lead to the production of an oncogene if it is in the wobble position of a codon that codes for leucine? Explain why or why not.
A single mutation has occurred in the following DNA sequence. 5' ATG TTC CAG CCA 3'...
A single mutation has occurred in the following DNA sequence. 5' ATG TTC CAG CCA 3' wild-type (normal) sequence 5' ATG TTC TAG CCA 3' mutant sequence a) Identify and classify the mutation according to its molecular structure (i.e., insertion, deletion base substitution (transversion), or base substitution (transition)). Briefly explain why you selected this classification. b) Identify and classify the mutation according to its functional effects (i.e., frameshift, missense, nonsense, or silent). Briefly explain why you selected this classification.
#1 Mutation 1. A chromosomes has the following segments, where represents the centromere: MNOPQRST Give the...
#1
Mutation 1. A chromosomes has the following segments, where represents the centromere: MNOPQRST Give the chromosome sequences that would result from the following mutations: a. Deletion of MN Pericentric inversion of NOP C. Inversion of RS, followed by tandem duplication of QRST b. 2. Which type(s) of chromosomal mutations: a. Increase the amount of genetic material in a particular chromosome? b. Increase the amount of genetic material in the entire genome? c. Decrease the amount of genetic material in...
Short Explain and tyoe please explain how a single base mutation can have a huge affect...
Short Explain and tyoe please explain how a single base mutation can have a huge affect on the expression of a gene. Why are most of these mutations devastating for gene expressions? How can they sometimes be beneficial? Use sickle-cell anemia as a case study for answering this question.
Explain why a gain-of-function mutation to a proto-oncogene (or its promoter) may be associated with increased...
Explain why a gain-of-function mutation to a proto-oncogene (or its promoter) may be associated with increased risk of cancer. (b) Explain why a loss-of-function mutation to a tumor suppressor gene may be associated with increased risk of cancer.
Please explain why,,
for the second prob, why is it not missense mutation..
20. The following bit of the human RefSeq includes the entire first exon of a protein coding gene and part of the second exon 5'-AACTAACCACTGTCCGTACTCTGCCAGCCATCCGTAGC-3' 21. The canonical splice junctions are 5'-GU....AG-3', where ... indicates additional intronic sequence. Which of the following is a candidate for the protein-coding portion of the processed mRNA from this sequence? a. 5'-TACCGACCGTCTACCAATAAC-3' b. 5'-GCTACGGATGGCTGGCAGAGT-3' c. 5' -GUACGGACAGUGGUUAGUUCC-3' d. 5'-AUGGCUGGCAGAUGGUUAGUU-3' e. 5'-AACTAACCATCTGCCAGCCAT-3'...
Mutations Worksheet-Dcletlon, Inserilon & SubstitutionThere are several types of mutations:> DELETION (a base is lost/deleted)> INSERTION (an extra base is added/inserted)- Deletion\& insertion may cause what's called a FRAMESHIFT mutation, meaning the reading "frame"changes, thus changing the amino acid sequence from this point forward > SUBSTITUTION (one base is substituted for another)- If a substitution changes the amino acid, it's called a MISSENSE mutation- If a substitution does not change the amino add, it's called a SILENT mutation- If a...
#1
Mutation 1. A chromosomes has the following segments, where represents the centromere: MNOPQRST Give the chromosome sequences that would result from the following mutations: a. Deletion of MN Pericentric inversion of NOP C. Inversion of RS, followed by tandem duplication of QRST b. 2. Which type(s) of chromosomal mutations: a. Increase the amount of genetic material in a particular chromosome? b. Increase the amount of genetic material in the entire genome? c. Decrease the amount of genetic material in...
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