What would be the protein target for albendazole compound for its computational studies
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What would be the protein target for albendazole compound for its computational studies
In RNA interference studies, the double-stranded RNA Select one: a. disrupts the target DNA sequence b. results in the destruction of the target mRNA c. destroys the target protein d. all of the above Hint: it's not D
1. what signal on a protein allows cells to target this protein to the right location? 2. how do cells distinguish sensory vs transmembrane pretty? 3. what are the major functions of ER 4. what control the fluidity of plasma membrane? why cholesterol can help maintain the integrity of the cell membrane ?
Compound X (structure below) is known to be a weak binder to the active site of protein target Y. SAR studies have determined the pharmacophore of Compound X (in blue). Give reactions schemes for two modifications that can be made to improve lipid membrane penetration with minimal impact on target binding.
18. A DNA-binding protein is needed to be expressed and purified for structural studies. It has the following properties: (a) It is a human protein; (b) The overall molecular mass is about 150 kDa; (c) It contains rare codons; (d) It has multiple charged and hydrophobic amino acid residues; (e) Its pI is 5.4; It is sensitive to proteolytic degradation. Starting from the design for protein expression using an appropriate expression system, briefly describe how you would proceed logically to...
Select one compound (drug or toxicant) that targets one of the three receptor types(G-protein coupled receptor pathway, A receptor tyrosine kinase pathway, An ion channel pathway ) and discuss the following for the selected compound: The name of the receptor involved The type of ligand that the drug or toxicant presents: Agonist, antagonist Are there natural ligands that interact with the receptor? If so explain the interaction. Provide a brief explanation of the mechanism of the cellular response upon ligand...
Of the choices below, why is protein synthesis an attractive target for the development of antibiotics? Proteins perform virtually every function of a cell, serving as both functional and structural elements, thus messing with their synthesis would lead to cell death O Protein synthesis is not typically a target for the production of antibiotics O Different amino acids are used by pathogens to build their proteins Proteins produced by pathogens are easily distinguished and eliminated by the host's immune system
What is protein X and what gene could be mutated to cause these results? Wild type Mutant DNA Protein X DNA Protein X Compound Compound Untreated US Protein X is a nuclear hormone receptor. The mutation is in protein X and it no longer binds compound S. Protein X is a nuclear hormone receptor. The mutation is in protein X and increases its affinity for compound Protein X is NFAT. The mutation is in the GPCR that binds compound U...
Question 2 (1 point) In order to target a protein to the endomembrane system, which of the following is required first? O a ER bound ribosome signal peptide on the N terminus of the polypeptide chaperone protein signal peptide on the C terminus of the polypeptide O signal-recognition particles A tRNA is chemically modified so that the amino acid bound is different than the one specified by its anticodon. Which codon in the mRNA would the tRNA recognize: the one...
d.) You would like to find a drug that slows the ability of Wnt signaling to activate its target genes. Beta catenin is not a very good target for drug discovery, because it is difficult to find drugs that specifically block a protein from binding to DNA or to other proteins. Suggest another way a hypothetical drug can block this pathway. Explain briefly what your drug will bind to, and how this reaction will end up affecting the rate of...
A cell contains a mutant SRP protein that cannot bind the normal signal sequence on target proteins. Explain how this would affect the endoplasmic reticulum structure AND function. How would cytoplasmic protein production be affected? Explain your reasoning.