State the physical and behavioral consequences associated with a GTP-binding protein when it undergoes GTP hydrolysis?
State the physical and behavioral consequences associated with a GTP-binding protein when it undergoes GTP hydrolysis?
Homework Answers
- G proteins are heteromeric, with alpha, beta and gamma subunits.
- Signalling molecule binding to G-protein, causes it to be stimulated or activated.
- The alpha-subunit possesses an intrinsic GTPase activity is activated resulting in conformational changes.
- It also serves as the GTP-binding domain.
- This causes a “switch on” of certain proteins in the alpha subunit by conformational changes of the alpha helices (that prevents the hydrolysis) of GTP in inactive state), like switch I and switch II.
- This mediates the GTPase activity and GTP hydrolysis.
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State the physical and behavioral consequences associated with a
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