The compound phenylthiocarbamide (PTC) tastes very bitter to most people. The inability to taste PTC is...
The compound phenylthiocarbamide (PTC) tastes very bitter to most people. The
inability to taste PTC is controlled by a single autosomal recessive allele. In the American white
population, about 70% can taste PTC while 30% cannot (are non-tasters). Estimate the
frequencies of the Taster (T) and non-taster (t) alleles in this population. How common are
carriers (those carrying the allele, but not displaying the phenotype) of the non-taster allele?
What assumption did you make to carry out your calculations
how to do i find the carriers?
Homework Answers
According to Hardy-Weinberg equation,
p + q = 1
and p2 + q2 + 2pq = 1
where p and q are the frequencies of the two alleles.
Non-taster is the recessive trait, so q2 = 0.3
q = 0.547
p = 1-q = 1 - 0.547 = 0.453
The frequency of carriers = 2pq = 2 * 0.453 * 0.547 = 0.495
Frequency of non-taster = q2 = 0.3
Frequency of taster = p2 + 2pq = 0.7
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