When a gene is mutated so that the resulting protein works at lower levels,this is called...
Homework Answers
When a gene is mutated so that the resulting protein works at lower levels,this is called a Loss of Function mutation, when a gene is mutated so that the resulting protein develops a new function this is called Gain of Function mutation
Explanation:
Loss of Function : Loss-of-function mutations in the heterozygous state would be associated with half normal levels of the protein product (haploinsufficiency mutation).
Gain of Function mutation: Gain-of-function mutations result in either increased levels of gene expression or the development of a new function(s) of the gene product.
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When a gene is mutated so that the resulting protein works at lower
levels,this is called...
What is protein X and what gene could be mutated to cause these results? Wild type...
What is protein X and what gene could be mutated to cause these results? Wild type Mutant DNA Protein X DNA Protein X Compound Compound Untreated US Protein X is a nuclear hormone receptor. The mutation is in protein X and it no longer binds compound S. Protein X is a nuclear hormone receptor. The mutation is in protein X and increases its affinity for compound Protein X is NFAT. The mutation is in the GPCR that binds compound U...
Changes in protein expression can alter gene function since: High levels of protein mean that the...
Changes in protein expression can alter gene function since: High levels of protein mean that the protein can sustain mutations more readily without any harm to the cell. The cell responds only to high levels of protein. Changes in expression can alter regulatory networks. Low levels of protein mean that the protein can sustain mutations more readily without any harm to the cell. The mutations found in the CF gene that result in cystic fibrosis are recessive because: The CF...
In bluebirds, there is an autosomal gene called the feather gene. This gene codes for the...
In bluebirds, there is an autosomal gene called the feather gene. This gene codes for the feather protein, and this protein controls the color of the feathers. A base- substitution mutation in the feather gene results in a bird with black feathers. When this black-feathered bird mates with a true-breeding normal blue-feathered bird (a black x normal cross), the F1 offspring all have normal blue feathers. Next to each statement below, indicate True or False. The black feather gene allele...
In pea plants, there is a gene called the pod gene. This gene codes for a...
In pea plants, there is a gene called the pod gene. This gene codes for a protein that limits the number of pea pods the plant can form. Farmers want to grow pea plants that produce more pods, so a scientist develops a chemical that binds to the pod protein and inactivates it. The scientist hypothesizes that exposing plants to the chemical will cause them to produce more pods. Describe a good experiment to test the scientist's hypothesis. Also describe...
Please answer 2-5 2. Consider a gene with a particular function. Mutation X and mutation Y...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
16. When a Cys residue in a protein is mutated to Asp, the protein loses its...
16. When a Cys residue in a protein is mutated to Asp, the protein loses its function. Which is the least likely explanation? A. The protein is part of ESCRT-O and therefore requires a disulfide bond at the Cys for stability. B. The protein is a Rab and the Cys is in a Caax prenylation motif. C. The protein is an E2 ubiquitin conjugating enzyme and the Cys is the attachment site for ubiquitin. D. The Cys is part of...
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1. You are interested in how cyclic-AMP-dependent protein kinase A (PKA) functions to affect learning and...
1. You are interested in how
cyclic-AMP-dependent protein kinase A (PKA) functions to affect
learning and memory, and you decide to study its function in the
brain. It is known that, in the cells you are studying, PKA works
via a signal transduction pathway like the one depicted in Figure
16-15. Furthermore, it is also known that activated PKA
phosphorylates the transcriptional regulator called Nerd that then
activates transcription of the gene Brainy. Which, if any
of the situations described...
(3 pts) There is a new mutation in the Lac/gene, called IN, that introduces a missense...
(3 pts) There is a new mutation in the Lac/gene, called IN, that introduces a missense mutation in the DNA binding domain of the protein. IN can not bind to the operator. Predict the outcome of the following lac operon genotype for the expression of functional lac enzymes in the different conditions indicated. (Note: + = wildtype, - = no functional protein made.) IN O+P+ Z-Y+ - lactose + lactose b-gal (Z) Permease (Y) b-gal (Z) Permease (Y) + +...
Why don't all x-linked genes demonstrate the gene dosage effect? Answer in terms of protein levels...
Why don't all x-linked genes demonstrate the gene dosage effect? Answer in terms of protein levels / activity / function in Drosophila.
What is protein X and what gene could be mutated to cause these results? Wild type Mutant DNA Protein X DNA Protein X Compound Compound Untreated US Protein X is a nuclear hormone receptor. The mutation is in protein X and it no longer binds compound S. Protein X is a nuclear hormone receptor. The mutation is in protein X and increases its affinity for compound Protein X is NFAT. The mutation is in the GPCR that binds compound U...
In bluebirds, there is an autosomal gene called the feather gene. This gene codes for the feather protein, and this protein controls the color of the feathers. A base- substitution mutation in the feather gene results in a bird with black feathers. When this black-feathered bird mates with a true-breeding normal blue-feathered bird (a black x normal cross), the F1 offspring all have normal blue feathers. Next to each statement below, indicate True or False. The black feather gene allele...
In pea plants, there is a gene called the pod gene. This gene codes for a protein that limits the number of pea pods the plant can form. Farmers want to grow pea plants that produce more pods, so a scientist develops a chemical that binds to the pod protein and inactivates it. The scientist hypothesizes that exposing plants to the chemical will cause them to produce more pods. Describe a good experiment to test the scientist's hypothesis. Also describe...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...
16. When a Cys residue in a protein is mutated to Asp, the protein loses its function. Which is the least likely explanation? A. The protein is part of ESCRT-O and therefore requires a disulfide bond at the Cys for stability. B. The protein is a Rab and the Cys is in a Caax prenylation motif. C. The protein is an E2 ubiquitin conjugating enzyme and the Cys is the attachment site for ubiquitin. D. The Cys is part of...
GENE EXPRESSION PROFILE A RELATIVE EXPRESSION CYCLIN D RB E2F Information for the following problem: • CYCLIN D inhibits RB • RB inhibits E2F • E2F increases mitosis 1. Is the pattern seen in gene expression profile A consistent with cancer progression? If so, explain why you have come to that conclusion 2. If consistent with cancer progression, indicate the probable gene that is mutated, and if this represents an oncogenic or tumor suppressor mutation. In your explanation, make sure...
1. You are interested in how
cyclic-AMP-dependent protein kinase A (PKA) functions to affect
learning and memory, and you decide to study its function in the
brain. It is known that, in the cells you are studying, PKA works
via a signal transduction pathway like the one depicted in Figure
16-15. Furthermore, it is also known that activated PKA
phosphorylates the transcriptional regulator called Nerd that then
activates transcription of the gene Brainy. Which, if any
of the situations described...
(3 pts) There is a new mutation in the Lac/gene, called IN, that introduces a missense mutation in the DNA binding domain of the protein. IN can not bind to the operator. Predict the outcome of the following lac operon genotype for the expression of functional lac enzymes in the different conditions indicated. (Note: + = wildtype, - = no functional protein made.) IN O+P+ Z-Y+ - lactose + lactose b-gal (Z) Permease (Y) b-gal (Z) Permease (Y) + +...
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