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Why have the centromeric regions of the human genome been difficult to sequence? What surprising discovery...

Why have the centromeric regions of the human genome been difficult to sequence? What surprising discovery was made when the centromeric region of Arabidopsiswas first sequenced?

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The centomere region is responsible for linking the pair of sister chromatids. The centomeric region is difficult to sequence because it contain mainly short repetitive DNA that is difficult to sequence and also the variation within these repetitive DNA that is mainly alpha satellite DNA is highly variable between humans . These two reasons make difficult to sequence the centomeric region of human genome.

The suprisingly discovery that was made while sequencing of centomeric region of arabidopsis is that centomere region of arabidopsis is very similar to the human centomere. The variation of repeats is also very similar between human and arabidosis are similar.

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