Question

Chapter 7 Section 7.7: Mutations and Their Effects Name: Problem 3: "normal" DNA: mRNA: Amino acids: TACCATTCGGGTCTCCTTGATCTGGCTATC "mutated" DNA: TACCATTCGGCGTCTCCTTGATCTG GCTAT C mRNA Amino acids What type of mutation is this (circle the correct answer)? Substitution/point mutation or frameshift mutation If a substitution/point mutation, what kind of substitution or point mutation is it (circle the correct answer)? Silent, missense, or nonsense Page 4 of 4

Answer 1

Normal DNA

mRNA :-

5' AUG GUA AGC CCA GAG GAA CUA GAC CGA UAG 3'

Amino acids :-

Met - Val - Ser - Pro - Glu - Glu - Leu - Asp - Arg

Mutated DNA

mRNA :-

5' AUG GUA AGC CGC AGA GGA ACU AGA CCG AUA G 3'

Amino acids :-

Met - Val - Ser - Arg - Arg - Gly - Thr - Arg - Pro - Ile

• This mutation is frameshift mutation as 'G' is incorporated in between thus the reading frame of codons is changed.