To figure out how a gene leads to disease, it needs to be analysed in both loss-of-function (LOF) and gain-of-function (GOF) studies. What do LOF and GOF studies tell you about a gene and why are they...
Homework Answers
From the LOF and GOF studies of a gene, following features were found - mutation type, reference allele, substituted allele, mutation impact, protein domain and sub-cellular location which can discriminate between LOF AND GOF mutations.These are important as it is useful in evaluating the significance of mutations on function of proteins based on evolutionary conservation of the sites of mutations.
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To figure out how a gene leads to disease, it needs to be analysed in both loss-of-function (LOF) and gain-of-function (GOF) studies. What do LOF and GOF studies tell you about a gene and why are they...
In Drosophila (fruit flies) the genes how, dumpy and ebony are located on chromosome 3. LOF...
In Drosophila (fruit flies) the genes how, dumpy and ebony are located on chromosome 3. LOF = loss of function. Flies homozygous for a LOF mutation (no gene product made) in ebony have dark black bodies. Flies homozygous for a LOF mutation (no gene product made) in dumpy have truncated (short) wings. Flies homozygous for a partial LOF mutation (some gene product made but significantly less than normal) in how have wings that will not fold down (held out wings;...
Case Scenario: Carrying the Gene Max and Mary are engaged. They are both 23 years old....
Case Scenario: Carrying the Gene Max and Mary are engaged. They are both 23 years old. A few years ago, when his grandfather became ill, Max discovered that his family carries the gene for Huntington’s disease. Huntington’s Disease is an adult onset progressively fatal neurological disease. The disease results in the death of brain cells and loss of muscle function. It is characterized by severe, uncoordinated, spontaneous jerking movements of the extremities. Loss of the ability to talk and swallow...
What do the variance, S.E., or standard deviation estimates tell you about your population that the...
What do the variance, S.E., or standard deviation estimates tell you about your population that the mean does not tell you? Why is it important to report some measure of variation, along with the sample size, whenever you report a calculated mean?
What can you tell about hoe Kodak did needs assessment for executive education? What recommendations would...
What can you tell about hoe Kodak did needs assessment for executive education? What recommendations would you give Kodak for improving this analysis, and what type of training do you think should be done now? How would you go about evaluating the effectiveness of these educational experiences? Do you believe that company profitability should be used as a criterion? Can more training save Kodak?
Assignment 1. - Word File Insert Design Layout References Mailings Review View Tell me what you...
Assignment 1. - Word File Insert Design Layout References Mailings Review View Tell me what you want to do Sign in Share Home Cut Find Aria E Copy Paste Select Editing Format Painter Clipboard Paragraph Font 9 leads to cell division when the target gene is transcribed. When the signal is present, will the target gene be Styles (5) The following is a diagram of the RTK signalling pathway. Assume that when the signal is present the pathway Ligand Receptor...
cant figure out final solution. how do you figure out . impact on 2017 income? Credit...
cant figure out final solution. how do you figure out . impact on
2017 income?
Credit No 1 Date Date 12/01/2017 General Journal Cost of goods sold Accounts payable (K) Debit 59,500.00 59,500.00 2 12/01/2017 No journal entry required P 3 12/31/2017 1,700.00 Foreign exchange loss Accounts payable (K) 1,700.00 12/31/2017 No journal entry required 5 12/31/2017 2,083.14 Forward contract Gain on forward contract 2,083.14 12/31/2017 No journal entry required 7 03/01/2018 2,550.00 Foreign exchange loss Accounts payable (K) 2,550.00...
how do you find foward contract and gain on forward contract? confused cant figure it out...
how do you find foward contract and gain on forward contract?
confused cant figure it out for 9/30. also how would you figure it
out on 10/31? can you please show work. thanks
Date September 15 September 30 October 31 Spot Rate $ 1.25 1.30 1.35 Forward Rate to October 31 $ 1.31 1.34 1.35 Call Option Premium for October 31 (strike price $1.25) $ 0.040 0.075 0.100 Vino Veritas Company, a U.S.-based importer of wines and spirits, placed an...
1. What value appeals do you find the most and least appealing? Why? 2. How might Maslow's hierarchy of needs help you d...
1. What value appeals do you find the most and least appealing? Why? 2. How might Maslow's hierarchy of needs help you develop a persuasive speech? 3. What are the core, authority and peripheral values of your anticipated audience? How could you find out?
use python to write You want to figure out how many days you spent in your...
use python to write You want to figure out how many days you spent in your highschool education. Assign the start and the end year for your highschool studies (or you can make up two years that are at least 2-4 years apart). For simplicity, we will not worry about the months or the actual dates. Write a program that will display how many days you had in that range (inclusive of both the years). For example, if you started...
Research an area of medical practice, and discuss what you initially thought about it, and how...
Research an area of medical practice, and discuss what you initially thought about it, and how your mind was changed after the research. In addition, discuss why you think the PRICE attributes are important as it relates to seeking an education. How do you think incorporating the PRICE Model into your life (academically as well as personally) will set you apart from others in the industry? Why do you think these attributes were the most commonly sought out behaviors? Are...
Assignment 1. - Word File Insert Design Layout References Mailings Review View Tell me what you want to do Sign in Share Home Cut Find Aria E Copy Paste Select Editing Format Painter Clipboard Paragraph Font 9 leads to cell division when the target gene is transcribed. When the signal is present, will the target gene be Styles (5) The following is a diagram of the RTK signalling pathway. Assume that when the signal is present the pathway Ligand Receptor...
cant figure out final solution. how do you figure out . impact on
2017 income?
Credit No 1 Date Date 12/01/2017 General Journal Cost of goods sold Accounts payable (K) Debit 59,500.00 59,500.00 2 12/01/2017 No journal entry required P 3 12/31/2017 1,700.00 Foreign exchange loss Accounts payable (K) 1,700.00 12/31/2017 No journal entry required 5 12/31/2017 2,083.14 Forward contract Gain on forward contract 2,083.14 12/31/2017 No journal entry required 7 03/01/2018 2,550.00 Foreign exchange loss Accounts payable (K) 2,550.00...
how do you find foward contract and gain on forward contract?
confused cant figure it out for 9/30. also how would you figure it
out on 10/31? can you please show work. thanks
Date September 15 September 30 October 31 Spot Rate $ 1.25 1.30 1.35 Forward Rate to October 31 $ 1.31 1.34 1.35 Call Option Premium for October 31 (strike price $1.25) $ 0.040 0.075 0.100 Vino Veritas Company, a U.S.-based importer of wines and spirits, placed an...
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