Question

State the three major types or groupings of antigens that the autoantibodies in SLE are targeted to and the isotype of the antibody associated with each.

Answer 1

The systemic lupus erythematosus (SLE) is a multisystem autoimmune condition characterised by autoantibodies directed against nuclear components.

The serology is found in SLE includes:

*Raised ANA titre - mainly homogenous or speckled pattern

*Raised anti-dsDNA antibodies

*Raised anti-Sm antibodies

*Raised phospholipid antibodies

*Reduced complement proteins (C3 and C4)

1. Antibodies to chromatin and histones: Homogenous ANA pattern

Here Isotype for the ANA antibody is IgG

2. Antibodies to ds-DNA: Peripheral ANA pattern

Here Isotype for the ds-DNA antibody is IgG

3. Anti-Smith = anti-snRNP (spliceosome)

There is no specific Isotype for snRNP antibody