4. Determine if Syl or Sn2 and the product formed. CH3OH CH3OH CH,OH CH3OH өОН DMF өОН 1112 DMSO NaCN DMSO
Conditions Starting Material Major Product(s) OH PBrg Et20 NaCN DMF OMs NaNH2 DMSO, 20'C 8 hr 1) NaH, DMF, -78°C 2) A ci NaOH Br OH
draw major product
CHCI 1) KOH/DMF HANNH, EIOH NaN, LAH THF NaCN LAH THF DMSO HONO, Hy/Ni CH,OH H2SO4 1) SOCI, /py LAH Hy/Ni CH,OH H. (cat) -H₂O NaBH,CN CH, OH
ETOH -Br heat - Br k. NaOH DMSO NaCN Br DMF m. OH Jones reagent
Starting Material Conditions OH PBr3 Eto C NaCN OMs DMF Br NaNH DMSO, 20°C 8 hr 1) NaH, DMF, -78°C 2) A ci NaOH
vero (S)-2-iodobutane NaSCH DMF -OH BIOCH3 Nal acetone NaCN acetone enou CH3OH for CH2OH CHCH
3. Determine if Sy1, S2, El or E2 and the product formed. Br CH,OH 1,0 c + CHCOOH ascol bus DMSO + CH,CH:09 acetone Br (CH),CO DME + 'OH acetronitrile X CH,OH 7,0
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (Syl, SN2, E1, or E2). NaOH HO CH3CH2ON CH3CH2OH CH ON CH OH Br CH,OH Na DMSO
1. Predict the product(s) (or no reaction) and reagent(s).
j. ETOH Br heat k. Br NaOH DMSO NaCN Br DMF m. РСС Н n. О H2SO4, H20 Н
Which statement or set of conditions listed below is not consistent with an Syl reaction pathway? O a. Neutral nucleophile work just fine. b. The leaving group is typically the conjugate base of a strong acid. O c. The rate is not dependent upon the concentration of the nucleophile. d. The temperature is relatively "cooler" to reduce competing elimination products. e. The solvent is polar and aprotic. Of. The substrate has a leaving group that is typically on a 30,...
identify (SN1,SN2, E1 or E2), write the product and
reactive, also the mecanism
Mecanismo Reacción Sna Н.сн.с. Н,С Br H3CH2C. он Her CH3 Hас "Cн, 2. CH -Br CHs OCH3 ON 1 3. LOCH CHeOH E O 4. HI (xs) CH3 X CH3OH H2SO4 6 -Grupo sadasnt Br NaCN SNO DMF Ederes 7. Nal acetona 8. CH, снон