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The dipeptide draw below has all of the ionisable groups in their conjugate acid forms together...
Lysine has pKa values as illustrated on the diagram below a) H3N ОН рК, 2.18 NH3 pKa 10.53 + рка, 8.95 Calculate the is...
Lysine has pKa values as illustrated on the diagram below a) H3N ОН рК, 2.18 NH3 pKa 10.53 + рка, 8.95 Calculate the isoelectric point for lysine i) Draw the predominant structure of lysine at pH>12 i b) The amino acid Tyrosine can be used in automated peptide synthesisers but this requires protected forms of the amino acid H2N ОН Он Tyrosine Show how you can synthesise N-protected and C-protected serine derivatives i) ii Show schematically a method to couple...
19) The form of dipeptide aspatylserine (Asp-Ser) obtained from two amino acids, aspartic acid an...
19) The form of dipeptide aspatylserine (Asp-Ser) obtained from two amino acids, aspartic acid and serine, whose structures are shown here, is HiN-CH-C-0HIN-CH-C-0 CH2 CH OH aspartic acid serine A HN-CH-C-o-N-CH-C-o CH OH CH2 coo -(H-C-o-H-c-o CH OH CH2 HIN CH-C-N-CH-C-O CH OH CH H-CH-CH CH CH OH coo- 20) Where is the peptide bond located in this dipeptide? serine valine a) the CO-NH joining serine and the valine b) the doubly bonded oxygen just left of center between the...
(d) Gaba, an important neurotransmitter in the human brain, is involved in epileptic seizures. Below are different form...
(d) Gaba, an important neurotransmitter in the human brain, is involved in epileptic seizures. Below are different forms that may or may not exist (depending on the local pH environment). Gaba has two ionizable functional groups, an amino group and a carboxylic acid, respectively. HON, HINO HN MNOH Hyeon Hawei OH (i) Circle the structure of GABA above that would be dominant at physiological pH = 7. correct answer circled) (2pts for (ii) Below, using the expression from 3(a), justify...
2. Using the reference pk values provided below (assuming that pk values can be applied to...
2. Using the reference pk values provided below (assuming that pk values can be applied to ionazable R groups in peptides) a) Draw the complete structure of the peptide IDKSMH that exists at physiological pH 7.4 b) What is the charge of the peptide at pH 7.4? c) What is the charge of the peptide at pH 10? PR, es pkk ) Rougl Amino acid COOH) Nonpolar, aliphatic Rgroups Glycine Alanine Proline Valine 1.99 10.98 Loucine 236 2.35 921 8.13...
2. A structure of Luminol is shown with all functional groups protonated and their pka labeled....
2. A structure of Luminol is shown with all functional groups protonated and their pka labeled. Use words and structures to answer a and b. Luminol pke 2 9 a. Acetic acid was added at the end of the reduction step to obtain a pH of - 3-4.2pts i. Draw the structure of the luminol at pH 3. ii. Refering to the structure in a.i.), explain why the luminol precipitates from the aqueous solution at this pH. NH₂ NH N-H...
explain the following answers 8. (3 pts) Consider the structure of histidine, shown below, along with...
explain the following answers
8. (3 pts) Consider the structure of histidine, shown below, along with the three pk, values of the three acidic groups. What is the isoelectric point (pl) for histidine? NH2 pka COOH = 1.77 = 6.10 pka, NH3+ = 9.18 pka, ning A) 3.94 C) 5.68 B) 5.48 D) 7.64 histidine OH 9. (3 pts) Which one of the following forms of histidine is the form that would mainly exist near pH = 4? HN NH2...
5. D-sorbital is found in 'sugar-free' chewing gum. It is formed by reducing D-glucose with NaBH Draw the structure of D-sorbital. s. (4 pts) Classify the following amino acid as polar, n...
5. D-sorbital is found in 'sugar-free' chewing gum. It is formed by reducing D-glucose with NaBH Draw the structure of D-sorbital. s. (4 pts) Classify the following amino acid as polar, non- polar, acidic, or basic: 6 (4 pts) The amino acid threonine (thr) has two chiral carbons. Draw a Fischer projection of the 2S,3S configuration of threonine. キ 7.(11 pts) Draw the tripeptide lys-asp-ser at physiological pH 8. (8 pts) The pK, values for aspartic acid are 2.10, 9.82...
Phosphoric acid (structure shown below) is a common acid used in buffer solutions. Even though the...
Phosphoric acid (structure shown below) is a common acid used in
buffer solutions. Even though the structure shows three equivalent
hydrogen atoms, there are three different pKa values associated
with the compound (pKa1 ≈ 2, pKa2 ≈ 7, pKa3 ≈ 12). Why do the three
hydrogen atoms have different pKa values? How many of the hydrogen
atoms will be removed in a buffer solution at pH 4?
OH HO-P-OH
C,D, and E i need help with. 17. The following peptide forms part of Human Hemoglobin...
C,D, and E i need help with.
17. The following peptide forms part of Human Hemoglobin subunit gammaa Asp-Leu-Lys-Gly-Thr-Phe-Ala A) Which amino acids are likely to be on the side of peptid acids are likely to be on the side of peptide that faces the interior of the protein? Insert your answer leu, Gto.Pne, Ala B) Which are likely to be facing the aqueous environment? Insert your answer Asp, lys, Thr Draw the structure of the sequence at pH7.4. Using...
2) Draw the 2 reactions of the weak acid, Carbonic Acid (H2CO3) with water. Which form...
2) Draw the 2 reactions of the weak acid, Carbonic Acid (H2CO3) with water. Which form of carbonic acid predominates at physiological pH? The two pKas of carbonic acid are the following: pK,1 = 6.4 pK,2 = 10.3. (3 points) 3) You have a 0.1 M solution of HCl in water. HCl is a strong acid. What is the pH of this solution? (Show your work or will not receive credit.) (2 pts.) 4) Calculate the pOH of a solution...
Lysine has pKa values as illustrated on the diagram below a) H3N ОН рК, 2.18 NH3 pKa 10.53 + рка, 8.95 Calculate the isoelectric point for lysine i) Draw the predominant structure of lysine at pH>12 i b) The amino acid Tyrosine can be used in automated peptide synthesisers but this requires protected forms of the amino acid H2N ОН Он Tyrosine Show how you can synthesise N-protected and C-protected serine derivatives i) ii Show schematically a method to couple...
19) The form of dipeptide aspatylserine (Asp-Ser) obtained from two amino acids, aspartic acid and serine, whose structures are shown here, is HiN-CH-C-0HIN-CH-C-0 CH2 CH OH aspartic acid serine A HN-CH-C-o-N-CH-C-o CH OH CH2 coo -(H-C-o-H-c-o CH OH CH2 HIN CH-C-N-CH-C-O CH OH CH H-CH-CH CH CH OH coo- 20) Where is the peptide bond located in this dipeptide? serine valine a) the CO-NH joining serine and the valine b) the doubly bonded oxygen just left of center between the...
(d) Gaba, an important neurotransmitter in the human brain, is involved in epileptic seizures. Below are different forms that may or may not exist (depending on the local pH environment). Gaba has two ionizable functional groups, an amino group and a carboxylic acid, respectively. HON, HINO HN MNOH Hyeon Hawei OH (i) Circle the structure of GABA above that would be dominant at physiological pH = 7. correct answer circled) (2pts for (ii) Below, using the expression from 3(a), justify...
2. Using the reference pk values provided below (assuming that pk values can be applied to ionazable R groups in peptides) a) Draw the complete structure of the peptide IDKSMH that exists at physiological pH 7.4 b) What is the charge of the peptide at pH 7.4? c) What is the charge of the peptide at pH 10? PR, es pkk ) Rougl Amino acid COOH) Nonpolar, aliphatic Rgroups Glycine Alanine Proline Valine 1.99 10.98 Loucine 236 2.35 921 8.13...
2. A structure of Luminol is shown with all functional groups protonated and their pka labeled. Use words and structures to answer a and b. Luminol pke 2 9 a. Acetic acid was added at the end of the reduction step to obtain a pH of - 3-4.2pts i. Draw the structure of the luminol at pH 3. ii. Refering to the structure in a.i.), explain why the luminol precipitates from the aqueous solution at this pH. NH₂ NH N-H...
explain the following answers
8. (3 pts) Consider the structure of histidine, shown below, along with the three pk, values of the three acidic groups. What is the isoelectric point (pl) for histidine? NH2 pka COOH = 1.77 = 6.10 pka, NH3+ = 9.18 pka, ning A) 3.94 C) 5.68 B) 5.48 D) 7.64 histidine OH 9. (3 pts) Which one of the following forms of histidine is the form that would mainly exist near pH = 4? HN NH2...
5. D-sorbital is found in 'sugar-free' chewing gum. It is formed by reducing D-glucose with NaBH Draw the structure of D-sorbital. s. (4 pts) Classify the following amino acid as polar, non- polar, acidic, or basic: 6 (4 pts) The amino acid threonine (thr) has two chiral carbons. Draw a Fischer projection of the 2S,3S configuration of threonine. キ 7.(11 pts) Draw the tripeptide lys-asp-ser at physiological pH 8. (8 pts) The pK, values for aspartic acid are 2.10, 9.82...
Phosphoric acid (structure shown below) is a common acid used in
buffer solutions. Even though the structure shows three equivalent
hydrogen atoms, there are three different pKa values associated
with the compound (pKa1 ≈ 2, pKa2 ≈ 7, pKa3 ≈ 12). Why do the three
hydrogen atoms have different pKa values? How many of the hydrogen
atoms will be removed in a buffer solution at pH 4?
OH HO-P-OH
C,D, and E i need help with.
17. The following peptide forms part of Human Hemoglobin subunit gammaa Asp-Leu-Lys-Gly-Thr-Phe-Ala A) Which amino acids are likely to be on the side of peptid acids are likely to be on the side of peptide that faces the interior of the protein? Insert your answer leu, Gto.Pne, Ala B) Which are likely to be facing the aqueous environment? Insert your answer Asp, lys, Thr Draw the structure of the sequence at pH7.4. Using...
2) Draw the 2 reactions of the weak acid, Carbonic Acid (H2CO3) with water. Which form of carbonic acid predominates at physiological pH? The two pKas of carbonic acid are the following: pK,1 = 6.4 pK,2 = 10.3. (3 points) 3) You have a 0.1 M solution of HCl in water. HCl is a strong acid. What is the pH of this solution? (Show your work or will not receive credit.) (2 pts.) 4) Calculate the pOH of a solution...
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