Even though the lac Z, Y, and A structural genes are transcribed as a single polycistronic mRNA, each gene contains the initiation and termination signals essential for translation. Predict what will happen when a cell growing in the presence of lactose contains a deletion of one nucleotide (a) early in the Z gene and (b) early in the A gene.
¦ H I NT: This problem requires you to combine your understanding of the genetic expression of the lac operon with that of the genetic code, frameshift mutation; and termination of transcription. The key to its solution is to consider the effect of the loss of one nucleotide within a polycistronic mRNA.
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