Homework Answers
Answer:(4) Lou Gehrig's disease/amyotrophic lateral sclerosis.
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All four of the neurodegenerative disorders discussed affect cognitive functions except: 1) Alzheimer's disease 2) Parkinson's...
1. Describe the blood brain barrier 2. Describe the pathophysiology of parkinson's disease 3. Describe the mechanism of...
1. Describe the blood brain barrier 2. Describe the pathophysiology of parkinson's disease 3. Describe the mechanism of action of the dopaminergic medications to treat parkinson's. How do these medications reduce symptoms? Is there a cure for parkinson's 4. Describe the pathophysiology of Alzheimer's Disease 5. Describe the mechanism of action of the drugs for cognitive impairment (page 193). How do these medications achieve a therapeutic effect in Alzheimer's disease. 6. Describe the pathophysiology of multiple sclerosis 7. Describe the...
1. Describe the blood brain barrier 2. Describe the pathophysiology of parkinson's disease 3. Describe the mechanism...
1. Describe the blood brain barrier 2. Describe the pathophysiology of parkinson's disease 3. Describe the mechanism of action of the dopaminergic medications to treat parkinson's. How do these medications reduce symptoms? Is there a cure for parkinson's 4. Describe the pathophysiology of Alzheimer's Disease 5. Describe the mechanism of action of the drugs for cognitive impairment (page 193). How do these medications achieve a therapeutic effect in Alzheimer's disease. 6. Describe the pathophysiology of multiple sclerosis 7. Describe the...
Gene mutations are likely involved in neurodegenerative disorders discussed. Based on the information presented, which mutations...
Gene mutations are likely involved in neurodegenerative disorders discussed. Based on the information presented, which mutations do you think would lead to DECREASED risk of these diseases? Mutations that INCREASE: 1) calcium diffusion 2) protein misfolding 3) prions 4) free radical formation 5) lysosomal activity
November 20, S8. Parkin is an 3 uhiquitin ligase that is mutased in familial Parkinson's disease....
November 20, S8. Parkin is an 3 uhiquitin ligase that is mutased in familial Parkinson's disease. Which protein is a arget of parkin-mediated ubiquitination? A. alpha synuclein dopamine D. prosine hydroxylase E. huntingtin 89. The following are all toxin models of Parkinson's except A. MPTP B. 6-hydroxydopamine C paraquat D. rotenone E. 3-nitropropionic ackd 90 la the basal ganglia, what is the effect of dopaminergic innervation to the striatal medium spiny GABAergic neurons? A. inhibition B. activation C, there is...
2. Ok... so, what is the α-synuclein mutant a mouse model of? (2 points) a) Parkinson’s disease...
2. Ok... so, what is the α-synuclein mutant a mouse
model of? (2 points) a) Parkinson’s disease b) Alzheimer’s disease
c) ALS
In your continued work at BigPharma, you are running additional experiments with previously developed, FDA approved drugs to see if they can be used off-label to assist with the treatment of neurodegenerative disorders. Originally, NeuroStop was developed to attenuate brain damage following stroke, and thus might be a good candidate drug for helping slow neurodegeneration. Presented here are data...
1. Define Alzheimer's disease and pre-Alzheimer's disease. 2. Identify the risk factors and prevalence of Alzheimer's disease. 3. Outline...
1. Define Alzheimer's disease and pre-Alzheimer's disease. 2. Identify the risk factors and prevalence of Alzheimer's disease. 3. Outline the course of Alzheimer's disease. 4. Compare and contrast the Global Deterioration Scale stages 1 to 7. 5. Discuss the main screening tools for Alzheimer's disease . 6. Identify Functional Assessment Staging stages 1 to 7. 7. Explain the psychopathology of Alzheimer's disease 8. Describe the potential physiological complications of Alzheimer's disease. 9. Relate the primary and differential diagnostic implications of Alzheimer's disease. 10.Define retro-genesis, and explain the evidence for...
2 .1 . 3. ..4... .6 21. List the cardinal symptoms of Parkinson's disease (p. 256...
2 .1 . 3. ..4... .6 21. List the cardinal symptoms of Parkinson's disease (p. 256 Parkinson's Disease) 22. Explain which neurons degenerate in Parkinson's disease (p. 257 Pathophysiology) 23. Explain the advantages of combining levodopa with carbidopa (p. 258 Dopaminergics) 24. List the four main types of side effects of carbidopa-levodopa (p. 262 Side Effects) 25. Explain the action of rivastigmine and describe how effective it is at treating Alzheimers (p. 264 Rivastigmine) 26 List the first 3 side...
Discussion Topics, Mohr Chapter 31, Cognitive Disorders Discussion Topics Learning Objective 1. After discussing cognitive disorders...
Discussion Topics, Mohr Chapter 31, Cognitive Disorders Discussion Topics Learning Objective 1. After discussing cognitive disorders in class, you begin thinking about experiences you have had with those who suffer from these conditions. What is a cognitive disorder? Have you ever had a family member who was diagnosed with a cognitive disorder? What feelings were evoked by the changes that result when someone has this kind of disorder? Think about any clients you may have cared for with a cognitive...
Note; Parkinson's Disease 3. What is the 1) incidence and 2) prevalence of PD in America?...
Note; Parkinson's Disease
3. What is the 1) incidence and 2) prevalence of PD in America? (2 pts) 4. Briefly describe what happens in the brain of people with PD (2 pts) 5. In your own words, how would you describe the PD severity of someone who is stage 3 on the Hoehn and Yahr scale? (1 pt)
Problem 1 [9 points]. Sickle cell disease (SCD) is a classification of disorders that affect red...
Problem 1 [9 points]. Sickle cell disease (SCD) is a classification of disorders that affect red blood cells such that they distort them into the shape of a crescent or sickle shape. Data was collected on age and prevalence of sickle cell disease of children, which we will use to examine any potential association between age and disease prevalance. The probabilities of each category can be estimated from the data by taking the relative frequency. For example, the probability that...
Gene mutations are likely involved in neurodegenerative disorders discussed. Based on the information presented, which mutations do you think would lead to DECREASED risk of these diseases? Mutations that INCREASE: 1) calcium diffusion 2) protein misfolding 3) prions 4) free radical formation 5) lysosomal activity
November 20, S8. Parkin is an 3 uhiquitin ligase that is mutased in familial Parkinson's disease. Which protein is a arget of parkin-mediated ubiquitination? A. alpha synuclein dopamine D. prosine hydroxylase E. huntingtin 89. The following are all toxin models of Parkinson's except A. MPTP B. 6-hydroxydopamine C paraquat D. rotenone E. 3-nitropropionic ackd 90 la the basal ganglia, what is the effect of dopaminergic innervation to the striatal medium spiny GABAergic neurons? A. inhibition B. activation C, there is...
2. Ok... so, what is the α-synuclein mutant a mouse
model of? (2 points) a) Parkinson’s disease b) Alzheimer’s disease
c) ALS
In your continued work at BigPharma, you are running additional experiments with previously developed, FDA approved drugs to see if they can be used off-label to assist with the treatment of neurodegenerative disorders. Originally, NeuroStop was developed to attenuate brain damage following stroke, and thus might be a good candidate drug for helping slow neurodegeneration. Presented here are data...
2 .1 . 3. ..4... .6 21. List the cardinal symptoms of Parkinson's disease (p. 256 Parkinson's Disease) 22. Explain which neurons degenerate in Parkinson's disease (p. 257 Pathophysiology) 23. Explain the advantages of combining levodopa with carbidopa (p. 258 Dopaminergics) 24. List the four main types of side effects of carbidopa-levodopa (p. 262 Side Effects) 25. Explain the action of rivastigmine and describe how effective it is at treating Alzheimers (p. 264 Rivastigmine) 26 List the first 3 side...
Note; Parkinson's Disease
3. What is the 1) incidence and 2) prevalence of PD in America? (2 pts) 4. Briefly describe what happens in the brain of people with PD (2 pts) 5. In your own words, how would you describe the PD severity of someone who is stage 3 on the Hoehn and Yahr scale? (1 pt)
Problem 1 [9 points]. Sickle cell disease (SCD) is a classification of disorders that affect red blood cells such that they distort them into the shape of a crescent or sickle shape. Data was collected on age and prevalence of sickle cell disease of children, which we will use to examine any potential association between age and disease prevalance. The probabilities of each category can be estimated from the data by taking the relative frequency. For example, the probability that...
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