Question

write a paper on
insulin and oral drugs for diabetes mellitus
HMGcoA reductase inhibitors

Answer 1

C to decrease insulin resistance - also decreases apetite Aduarse effects: andesis Hart hypoglycemie, sare lectie Thiszolidinediones: ( pingletasone e rosglitazones mest principally at adipose time & skeletal suk affeces. weight gain, repeti da functions Alphaglucosidese inhibitors : ( Acarbose ay mighted) thered at sehening of meet, taley conting grote these agents are oigosacharide derivatives Adverse reaction plat alene, dierka, * a with soылар < імен Mong (A Reductese intibitors & Stations ) - Lower cholesterd level of inhibiting enzyme ting CoA reductase whith flays role in production of cholested in liver - Lide effects Muscle toxicity a CS Scanned with GI disturbences, pancreatitis joundice CamScanner

Confreienfications: Porphyria, Aure liver disease, pregnancy, breast feeding Scanned with CamScanner

Opal typoglycemin - weful in treatment of type 2 Diabetes mellitus who don't respond to hon medical intervention as Sulphonylureas : promote release of insulin o From B cello. sharelate release by blocking ATP sensitive kt Channels resulting in depolerisation with 66²4 influp whech frontes insulin secreterin Reduce fluogon secretion. The Aduerse Ron Weight gain, Hyperinsulinemia, au hypogledom nyperinsuikenemis, by Meglitiniges Pringt feak effect ( I lower u Shast duration of action ( 4 hrs) a Shuld be taken 15% men before meals. - used along with bad hypoglycemics to better control (Biguanides (metformin) incloses glucose uptake y Wilisation by target tissues. -Redures plesne please send by inhibiting hepatic gluconeof enesis ühes Scanned with CamScanner

Insulin - peride hormone synthessed in B cells of islets of Longarhons in fencreas Mechanism of action: Causes diffusion of glucose into cells. Smulates uptake of amino acids, potestiune le mafiesieni i Smuletes protein synthesis y inhitit propesyon ai. Pharmacokinetics : • Elimination ath of IV insulend= 5-tomir Metabolised by kidneys alver Onset Duration Rapid acting ( Regular insulin) 0.5-1. 48 Very Reped acting (Lespro, aspart) 10.25-0.5 46 Intermediate atting (rente) í lof Long Acting (glangines ho 18:30 Adverse effect: typoglycame islergic reacting Tuolyesteaply, hypokalemie , weight Jain Scanned with CamScanner