Question

In order to estimate the renal clearance of a drug in a patient, a 2-hour post dose urine sample was collected and found to contain 200 mg of drug. A mid-point (1 h) plasma sample was taken and the concentration was found to be 2.5 mg/dL. Estimate the renal clearance for this drug.

Answer 1

The equation for calculating the renal clearance of drug X (ClX, with units expressed as volume per time; e.g., ml/min) is:

ClX = (UX) • (V)/ PX;

where UX is the concentration of drug X in the urine (mg/ml), V is the urine flow rate (ml/min), and PX is the concentration of drug X in the plasma (mg/ml).

Clx = 200mg * V/2.5

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