Question

What are two major factors that contribute to DNA double-strand break repair pathway choice(HDR, NHEJ, or Alt.NHEJ)? Please explain

Answer 1

we and non- NYHEJ in order to achive repair a diverse range of substrate 9. What are two major factures that contribute to DNA double 8strand break repair Pathway Choice (HDR, MHEJ or Alt. NHE)) ? Please explain Any Double Strind DNA breaks ane : Conor events in eukomotic cells, and there two major Pabbiays for repairing. Meno :- homologous recombination n-homologam oma and Joining The diverse came of DSBs reaults in diverse chemishy of DNA endo that munst be repairs Across NHEJ evolution the enzyme of Paltway exbinits a remowkahle degree of structural tolerance in stu range of DNA end Bubshrato Configuration upon which they can act. In the verchibale cells the nuclease, Poly ligare of Mihej One most mechanically flexible and multifunctional enzymes In each of She clones, unlike repair NHEJ repair enzymes ack ikeratively act in order and can functton independenly of another of each of the two Dra ends being Joined unlike most oltur DNA repur and DNA recombination pathways Mon- -homologous DNA ends Joining CMHET) in prownieke cand eukariote evolved withing themes of mechanische fleximility, enzyme multinationally and inter altre processing DNA end of the double-strand breakes (ASBs) except for every limiting protein homology for ku protein in Prokariots and eukariots the actual nucleane merases and defined lesions. Pathways for more any one CS Scanned with CamScanner

polymerase and ligne me components of NHAS appear to have arisen independently but Converged on these same mechanistic shemes in order handle the challenge of joining to freely diffusing endo of diverse Dnia overhang configuration with a wide range of borse or sugar oxidative damage fo end CS Scanned with CamScanner