Which of the following is NOT a function of homologous recombination? Repair of DNA double strand...
Which of the following is NOT a function of homologous recombination?
- Repair of DNA double strand breaks
- Repairing bulky DNA damage
- Pairing of homologous chromosomes in meiosis
- Rescue of collapsed replication forks
Homework Answers
Question
Homologous recombination involve exchange of nucleotide sequence between two similar or identical DNA and RNA strands. This type of recombination mainly help in repairing of double strand DNA, help in pairing of homologous recombination and also help in rescue of collapsed replication fork. But homologous recombination is not use in repairing bulky damage of DNA and is often performed by nucleotide excision repair. Hence, option b is incorrect.
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Which of the following is NOT a function of homologous
recombination?
Repair of DNA double strand...
z Instructions Question 1 (Q039) In addition to the repair of DNA double-strand breaks, homologous recombination...
z Instructions Question 1 (Q039) In addition to the repair of DNA double-strand breaks, homologous recombination is a mechanism fe generating genetic diversity by swapping segments of parental chromosomes. During which process does swapping occur? DNA replication ODNA repair O meiosis transposition No new data to save. Last checked at 8:05am
The process of homologous recombination is a means to repair double-strand breaks, the most lethal form...
The process of homologous recombination is a means to repair double-strand breaks, the most lethal form of DNA damage. Arrange the sequence of events in the proper order: 1. ATR recognizes single-stranded ends, binds to them, and initiates signaling. 2. RAD51 complexes with ssDNA and searches for homologous sequences. 3. MRN nuclease trims the 5' ends, leaving ss-3' ends that are coated with replication protein A. 4. ATM activates a nuclease in MRN and signals downstream effectors. 5. RAD51-ssDNA complex...
Sort the following steps for repairing double-strand breaks by homologous recombination a) Ligation b) DNA synthesis...
Sort the following steps for repairing double-strand breaks by homologous recombination a) Ligation b) DNA synthesis using undamaged DNA as template c) DNA synthesis using original DNA as template d) Release of the invading strand e) Strand invasion f) Nuclease digestion (resection)
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end...
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end joining) are especially sensitive to agents that cause double-strand breaks in DNA. If the breaks occur in the G1 phase of the cell cycle, most cells will die; however, if the breaks occur in the G2 phase, a much higher fraction of cells survive. Why do you suppose this is?
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______...
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______ a) meiosis b) mitosis c) both 3. Homologous recombination in meiosis has the main purpose of_____ a) DNA repair b) Creating new chromosomes c) Sealing double-stranded breaks 4. Strand invasion usually happens without enzymatic assistance. T/F? 5. When replication fork runs into a nick, it results in a_______ a) single-stranded break b) double-stranded break 6. The invading end is usually a _______ a) 3'...
Ionizing radiation and oxidative damage can cause DNA double-strand breaks. A. True. B False Nucleotide Excision...
Ionizing radiation and oxidative damage can cause DNA double-strand breaks. A. True. B False Nucleotide Excision Repair involves recognition of distortions in the DNA double helix rather than specific base changes. A. True. B False Homologous recombination does not occur in prokaryotic cells. A. True. B False Many chemotherapeutic agents are paradoxically DNA damaging agents A. True. B False Meiot.c recombination starts with, double-strand break caused by errors In DNA replication A. True. B False ONA replication origins are typically...
Which of the following is NOT a telomeric function? Facilitating chromosome reorganization for efficient pairing and...
Which of the following is NOT a telomeric function? Facilitating chromosome reorganization for efficient pairing and recombination of homologous chromosomes during meiosis Protection of the chromosome end Allowing extension of the telomere. Providing a site of origin for DNA replication.
q39 Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a...
q39
Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information. Which of the following is necessary for homologous recombination to occur? telomerase O 3 DNA strand overhangs • a short stretch of sequence similarity no DNA strand overhangs
2 For each of the following DNA lesions, indicate which repair pathway would be most directly...
2 For each of the following DNA lesions, indicate which repair pathway would be most directly involved in repairing the damage. For this question, select the best answer for each. b. MMR 8-oxo-G G:T base pair cisplatin-induced interstrand crosslink a. BER C. NER d. HR e NHEJ _UV-induced 6-4 photoproduct (pyrimidine dimer) X-ray induced double strand break in a neuron collapsed replication fork _deamination-induced uracil
5. About double strand DNA repair, it is correct to say that choose the most appropriate answer):
5. About double strand DNA repair, it is correct to say that choose the most appropriate answer): (a) It requires one intact strand as a template for error correction. (b) Mismatches in the DNA are usually corrected via double strand DNA repair mechanisms. (c) Homologous recombination usually results in DNA repair with no loss of nucleotide at repair site. (d) Non-homologous end-joining usually results in DNA repair with no loss of nucleotide at repair site. 6. A eukaryote gene has two introns and three exons....
z Instructions Question 1 (Q039) In addition to the repair of DNA double-strand breaks, homologous recombination is a mechanism fe generating genetic diversity by swapping segments of parental chromosomes. During which process does swapping occur? DNA replication ODNA repair O meiosis transposition No new data to save. Last checked at 8:05am
The process of homologous recombination is a means to repair double-strand breaks, the most lethal form of DNA damage. Arrange the sequence of events in the proper order: 1. ATR recognizes single-stranded ends, binds to them, and initiates signaling. 2. RAD51 complexes with ssDNA and searches for homologous sequences. 3. MRN nuclease trims the 5' ends, leaving ss-3' ends that are coated with replication protein A. 4. ATM activates a nuclease in MRN and signals downstream effectors. 5. RAD51-ssDNA complex...
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end joining) are especially sensitive to agents that cause double-strand breaks in DNA. If the breaks occur in the G1 phase of the cell cycle, most cells will die; however, if the breaks occur in the G2 phase, a much higher fraction of cells survive. Why do you suppose this is?
Ionizing radiation and oxidative damage can cause DNA double-strand breaks. A. True. B False Nucleotide Excision Repair involves recognition of distortions in the DNA double helix rather than specific base changes. A. True. B False Homologous recombination does not occur in prokaryotic cells. A. True. B False Many chemotherapeutic agents are paradoxically DNA damaging agents A. True. B False Meiot.c recombination starts with, double-strand break caused by errors In DNA replication A. True. B False ONA replication origins are typically...
q39
Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information. Which of the following is necessary for homologous recombination to occur? telomerase O 3 DNA strand overhangs • a short stretch of sequence similarity no DNA strand overhangs
2 For each of the following DNA lesions, indicate which repair pathway would be most directly involved in repairing the damage. For this question, select the best answer for each. b. MMR 8-oxo-G G:T base pair cisplatin-induced interstrand crosslink a. BER C. NER d. HR e NHEJ _UV-induced 6-4 photoproduct (pyrimidine dimer) X-ray induced double strand break in a neuron collapsed replication fork _deamination-induced uracil
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