Homework Answers
Homologous recombination brings the genetic diversity by swapping the parental DNA. Genetic diversity occurs when the two different DNAs are swapped (one from father and other from the mother).
In DNA replication, DNA belonging to one person replicates to form exact copy of that strand. It doesn't bring genetic diversity.
DNA repair also causes the conversion of defective segment into the original normal segment. It doesn't cause any diversity.
Transposition means movement of one DNA segment from one genomic site to other genomic site.
During the process of Meiosis, homologous recombination occurs prophase 1. During this phase, chromosomal segments line in pairs and swap their DNA to bring about genetic diversity.
Answer is meiosis.
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z Instructions Question 1 (Q039) In addition to the repair of DNA double-strand breaks, homologous recombination...
Which of the following is NOT a function of homologous recombination? Repair of DNA double strand...
Which of the following is NOT a function of homologous recombination? Repair of DNA double strand breaks Repairing bulky DNA damage Pairing of homologous chromosomes in meiosis Rescue of collapsed replication forks
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end...
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end joining) are especially sensitive to agents that cause double-strand breaks in DNA. If the breaks occur in the G1 phase of the cell cycle, most cells will die; however, if the breaks occur in the G2 phase, a much higher fraction of cells survive. Why do you suppose this is?
The process of homologous recombination is a means to repair double-strand breaks, the most lethal form...
The process of homologous recombination is a means to repair double-strand breaks, the most lethal form of DNA damage. Arrange the sequence of events in the proper order: 1. ATR recognizes single-stranded ends, binds to them, and initiates signaling. 2. RAD51 complexes with ssDNA and searches for homologous sequences. 3. MRN nuclease trims the 5' ends, leaving ss-3' ends that are coated with replication protein A. 4. ATM activates a nuclease in MRN and signals downstream effectors. 5. RAD51-ssDNA complex...
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______...
1. Homologous recombination can happen between non-identical DNA sequences. T/F? 2. Homologous recombination can happen in_______ a) meiosis b) mitosis c) both 3. Homologous recombination in meiosis has the main purpose of_____ a) DNA repair b) Creating new chromosomes c) Sealing double-stranded breaks 4. Strand invasion usually happens without enzymatic assistance. T/F? 5. When replication fork runs into a nick, it results in a_______ a) single-stranded break b) double-stranded break 6. The invading end is usually a _______ a) 3'...
Sort the following steps for repairing double-strand breaks by homologous recombination a) Ligation b) DNA synthesis...
Sort the following steps for repairing double-strand breaks by homologous recombination a) Ligation b) DNA synthesis using undamaged DNA as template c) DNA synthesis using original DNA as template d) Release of the invading strand e) Strand invasion f) Nuclease digestion (resection)
Ionizing radiation and oxidative damage can cause DNA double-strand breaks. A. True. B False Nucleotide Excision...
Ionizing radiation and oxidative damage can cause DNA double-strand breaks. A. True. B False Nucleotide Excision Repair involves recognition of distortions in the DNA double helix rather than specific base changes. A. True. B False Homologous recombination does not occur in prokaryotic cells. A. True. B False Many chemotherapeutic agents are paradoxically DNA damaging agents A. True. B False Meiot.c recombination starts with, double-strand break caused by errors In DNA replication A. True. B False ONA replication origins are typically...
q39 Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a...
q39
Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information. Which of the following is necessary for homologous recombination to occur? telomerase O 3 DNA strand overhangs • a short stretch of sequence similarity no DNA strand overhangs
Mismatch repair requires all of the following EXCEPT: Requires information from a nearby homologous chromosome Uses...
Mismatch repair requires all of the following EXCEPT: Requires information from a nearby homologous chromosome Uses information on the parental strand to identify the error. Is tightly associated with new replicated DNA Makes use of ligase. Requires the use of a repair DNA polymerase. Question 12 Which of the following is NOT necessary for homologous recombination to occur? O nucleases 5' DNA strand overhangs 3' DNA strand overhangs ligase a long stretch of sequence similarity Which of the following apply...
Explain the discovery, mechanism of action and function of AID (activation-induced deaminase)? SOMATIC HYPERMUTATION (Figures 7...
Explain the discovery, mechanism of action and function of AID
(activation-induced deaminase)?
SOMATIC HYPERMUTATION (Figures 7 and 8). Indeed, the discovery of AID provided the missing MSH2-deficient mice had previously been taken to indicate that somatic mutation is initiated by diversification at C:G pairs with MSH2-mediated recognition then triggering a subsequent stage of diversification at A:T pairs. Such a two-stage model was supportedations by the observation that CG-biased mutation was also a characteristic of somatic mutation in B-c nes9 and...
Haploid yeast cells that preferentially repair double-strand breaks by homologous recombination (rather than by non-homologous end joining) are especially sensitive to agents that cause double-strand breaks in DNA. If the breaks occur in the G1 phase of the cell cycle, most cells will die; however, if the breaks occur in the G2 phase, a much higher fraction of cells survive. Why do you suppose this is?
The process of homologous recombination is a means to repair double-strand breaks, the most lethal form of DNA damage. Arrange the sequence of events in the proper order: 1. ATR recognizes single-stranded ends, binds to them, and initiates signaling. 2. RAD51 complexes with ssDNA and searches for homologous sequences. 3. MRN nuclease trims the 5' ends, leaving ss-3' ends that are coated with replication protein A. 4. ATM activates a nuclease in MRN and signals downstream effectors. 5. RAD51-ssDNA complex...
Ionizing radiation and oxidative damage can cause DNA double-strand breaks. A. True. B False Nucleotide Excision Repair involves recognition of distortions in the DNA double helix rather than specific base changes. A. True. B False Homologous recombination does not occur in prokaryotic cells. A. True. B False Many chemotherapeutic agents are paradoxically DNA damaging agents A. True. B False Meiot.c recombination starts with, double-strand break caused by errors In DNA replication A. True. B False ONA replication origins are typically...
q39
Question 39 0.35 pts Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information. Which of the following is necessary for homologous recombination to occur? telomerase O 3 DNA strand overhangs • a short stretch of sequence similarity no DNA strand overhangs
Mismatch repair requires all of the following EXCEPT: Requires information from a nearby homologous chromosome Uses information on the parental strand to identify the error. Is tightly associated with new replicated DNA Makes use of ligase. Requires the use of a repair DNA polymerase. Question 12 Which of the following is NOT necessary for homologous recombination to occur? O nucleases 5' DNA strand overhangs 3' DNA strand overhangs ligase a long stretch of sequence similarity Which of the following apply...
Explain the discovery, mechanism of action and function of AID
(activation-induced deaminase)?
SOMATIC HYPERMUTATION (Figures 7 and 8). Indeed, the discovery of AID provided the missing MSH2-deficient mice had previously been taken to indicate that somatic mutation is initiated by diversification at C:G pairs with MSH2-mediated recognition then triggering a subsequent stage of diversification at A:T pairs. Such a two-stage model was supportedations by the observation that CG-biased mutation was also a characteristic of somatic mutation in B-c nes9 and...
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