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Describe the segmented genome for influenza and the implications it has for antigenic shift.

Describe the segmented genome for influenza and the implications it has for antigenic shift.

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The genomes of all influenza viruses are composed of eight single-stranded RNA segments. These RNAs are negative-sense molecules, meaning that they must be copied into positive-sense molecules in order to direct the production of proteins.

The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift.

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