Homework Answers
Major histocompatibility
complex (MHC): These are the proteins expressed on the
surface of the cells. Antigen-presenting cells like a macrophage,
dendritic cells, Langerhans cells, and B cells are the cells engulf
the whole antigen, process it with the help of proteasomal
degradation into small peptides. The processed peptides are present
on the surface of the APCs and these peptides are then recognized
by the T-cell receptors. On the basis of the type of peptide, the
type of MHC represents it and the specific T-cell recognizes
it.
The difference between MHC I and MHC II:
|
Serial number |
MHC I | MHC II |
| 1 |
It has three alpha domain and one beta domain. |
The has two alpha and two beta domain. |
| 2 | A single alpha domain span the membrane. | The spanning domain is one alpha and one beta. |
| 3 | It presents the antigen to cytotoxic T-cells. | It presents the antigen to helper T-cells. |
| 4 | The peptide is recognized by the CD-8 receptor present on the cytotoxic T cell. | The peptide is recognized by the CD-4 receptor present on the helper T cell. |
| 5 | MHC I is present on the cell surface of all the nucleated cells. | MHC II is present on the APCs. |
| 6 | It represents the endogenous antigens. | It represents the exogenous antigens. |
| 7 | It does not have an invariant chain. | It has an invariant chain. |
| 8 | The major types of MHC I are MHC-A, MHC-B, and, MHC-C. | The major types of MHC II are MHC-D. |
| 9 | The function is the clearance of endogenous antigens. | The function is the clearance of exogenous antigens. |
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seen with immunological responses that involve both the MHC class I
and the MHC class II molecules. Define MHC class I and class II
restriction, which molecules and cells are involved and which stage
of the immune response (stages 1 – 8 in figure 1-7 on page 20) the
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