Very briefly explain how five types of cancer- genes are involved in tumor progression
Very briefly explain how five types of cancer- genes are involved in tumor progression
Homework Answers
Many genes are linked with cancer. Tumour suppressor genes regulate the cell growth by repairing mismatches, monitoring how fast the cell divides and controlling the cell death.Mutation in it leads to tumour progression.BRCA 1 and BRCA2 mutation can cause breast and ovarian cancer. Another important gene isp53. around 50% of cancers are due to mutated p53.
Oncogenes are genes that convert a healthy cell into a cancerous one. Example HER2 and ras family gene. They are responsible for cancer cells growth and spread. Then malfunctiong of DNA repair genes too result in cancer.
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Very briefly explain how five types of cancer- genes are
involved in tumor progression
a. To cause cancer, proto-oncogenes require considered mally, tumor suppressor genes inhibit the cell cycle. How...
a. To cause cancer, proto-oncogenes require considered mally, tumor suppressor genes inhibit the cell cycle. How do mutated tumor suppressor Ben cell cycle? allele(s) to be mutated and therefore are - The mutation results in a of function. nor suppressor genes affect the a. To cause cancer, tumor suppressor genes require allele(s) to be mutated and therefore are considered - The mutation results in a _ _ of function.
1. Inflammation can play a role in cancer (development and/or progression) in which of the following...
1. Inflammation can play a role in cancer (development and/or progression) in which of the following ways? Select all that apply. Question options: A) TILs can secrete pro-inflammatory cytokines that promote cancer. B) TAMs can attack cancer cells and destroy them. C) Ulcerative colitis can progress to colon cancer. D) Immune cells associated with a cancer can secrete angiogenic and growth factors. E) Hepatitis C infection can lead to liver cancer. F) Hypercholesterolemia can develop into leukemia. 2. Tumor suppressor...
BRCA1 and BRCA2 are tumor suppressor genes that have been associated with breast cancer development due...
BRCA1 and BRCA2 are tumor suppressor genes that have been associated with breast cancer development due to mutations of these genes being linked to a subset of breast cancers. If an individual carries one nonfunctional copy of the BRCA gene, will all of their cells be affected? Explain.
Contrast what tumor suppressor genes and proto-oncogenes do in their normal and cancer-promoting states. Normal ...
Contrast what tumor suppressor genes and proto-oncogenes do in their normal and cancer-promoting states. Normal Cancer-promoting Tumor suppressor gene (Proto-)oncogene
3. (36 pts) Mutations of the following groups of genes are associated with cancer. Briefly describe:...
3. (36 pts) Mutations of the following groups of genes are associated with cancer. Briefly describe: 1) Their normal functions, including the related signaling pathways and cell behaviors; 2) Their oncogenic roles: the effects of their mutants to cell behaviors in cancers (oncogene or tumor suppressor, gain or loss of function) BAD/Bcl2/Bax Rb/E2F Cdk/cyclin Akt/mTOR
Explain the figures below METHYLATION IMBALANCE may contribute to TUMOR PROGRESSION GLOBAL HYPOMETHYLATION DNA HYPERMETHYLATION Observed...
Explain the figures below
METHYLATION IMBALANCE may contribute to TUMOR PROGRESSION GLOBAL HYPOMETHYLATION DNA HYPERMETHYLATION Observed in neoplastic cells Inactivation of tumor- suppressor genes: p16, BRCA1 May induce neoplastic transformation Inactivation of DNA repair genes: MLH1, MGMT Genomic instability, Abnormal chromosomal structures and Activating oncogenes. Pregnancy Placenta Childhood Adulthood DNA sequence variation 201 cis-meOTL SNPS 22 CpGs in adult blood associated with cardiometabolic dysfunctions Change in placental ONA methylation (24 CpGs associated Change in placental DNA Maternal SBPIDBP Methylation Regulatory...
Outline the molecular changes required for initiation and progression of colorectal cancer. How could these molecular...
Outline the molecular changes required for initiation and progression of colorectal cancer. How could these molecular changes be exploited to assist with diagnosis and treatment? Selective differentiation of iPSCs can be used to generate a broad range of cell types. Outline how iPSCs reprogramming is currently being applied for cancer research. Discuss how this technology can improve our ability to model cancer behaviour for more efficient drug discovery. Outline the epigenetic changes starting with a differentiated cell, to the partially...
PATH370 2018 - risk factors/predisposing factors for carcinogenesis: tobacco, nutrition, genetics (proto-oncogenes, oncogenes, tumor suppressor genes),...
PATH370 2018 - risk factors/predisposing factors for carcinogenesis: tobacco, nutrition, genetics (proto-oncogenes, oncogenes, tumor suppressor genes), viruses - role of p53 and Rb carcinogenesis: what is initiation, promotion, progression? - carcinogen vs mutagen vs teratogen - metastasis: define/describe, pattern of spread, tumor markers, angiogenesis, grading/staging, most common organs where metastasis occurs, first place of metastasis for many cancers - TNM system: what does each letter represent, are low or high number more severe? - generalized effects of cancer on the...
1. a) Mutations in genes encoding certain mitochondrial proteins are associated with certain types of cancer....
1. a) Mutations in genes encoding certain mitochondrial proteins are associated with certain types of cancer. How can defective mitochondria lead to cancer? b) Why is the structure of the mitochondria suitable for containing the metabolic processes?
How can the role of epigenetics in cancer be reconciled with the idea that cancer is...
How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of mutations in tumor-suppressor genes and proto-oncogenes?
a. To cause cancer, proto-oncogenes require considered mally, tumor suppressor genes inhibit the cell cycle. How do mutated tumor suppressor Ben cell cycle? allele(s) to be mutated and therefore are - The mutation results in a of function. nor suppressor genes affect the a. To cause cancer, tumor suppressor genes require allele(s) to be mutated and therefore are considered - The mutation results in a _ _ of function.
Explain the figures below
METHYLATION IMBALANCE may contribute to TUMOR PROGRESSION GLOBAL HYPOMETHYLATION DNA HYPERMETHYLATION Observed in neoplastic cells Inactivation of tumor- suppressor genes: p16, BRCA1 May induce neoplastic transformation Inactivation of DNA repair genes: MLH1, MGMT Genomic instability, Abnormal chromosomal structures and Activating oncogenes. Pregnancy Placenta Childhood Adulthood DNA sequence variation 201 cis-meOTL SNPS 22 CpGs in adult blood associated with cardiometabolic dysfunctions Change in placental ONA methylation (24 CpGs associated Change in placental DNA Maternal SBPIDBP Methylation Regulatory...
PATH370 2018 - risk factors/predisposing factors for carcinogenesis: tobacco, nutrition, genetics (proto-oncogenes, oncogenes, tumor suppressor genes), viruses - role of p53 and Rb carcinogenesis: what is initiation, promotion, progression? - carcinogen vs mutagen vs teratogen - metastasis: define/describe, pattern of spread, tumor markers, angiogenesis, grading/staging, most common organs where metastasis occurs, first place of metastasis for many cancers - TNM system: what does each letter represent, are low or high number more severe? - generalized effects of cancer on the...
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