Question

how does the microbiome prevent colon cancer

Answer 1

Diet have a great role in regulating micribiome in get. Certain food that contain fiber are required to improve and maintain a good microflora. Dysbiosis and Immune Dysfunctions in Colon Carcinogenesis can be caused in case of lack of microbiota based on the presence of pathogenic or opportunistic microbes in the gut. Beneficial microbes can prevent inflammation and tumorigenesis. Lactobacillus , bifidobacterium prevotella are present in a healthy gut and these help to maintain proper homeostasis. These microbes helps in release of anti inflammatory cytokines, anti oxidants,  molecules that help in DNA damage repair.
While any dysbiotic microbiota could lead to chronic inflammation, increased IL-6 signaling, and tumorigenesis. I IL-6 activates STAT3
signaling, prevent cells from apoptosis. Microorganism-associated molecular patterns
(MAMPs) are detected by Toll-like receptors (TLRs) on gut epithelium and can helps the activation of pathways
that promote development of colon cancer.