4. Draw the structure of a functional antigen receptor on T cells. (1.0)
True or False: Chimeric antigen receptor (CAR) T cells are cells that have been retrovirally transduced with a tumor- specific T-cell receptor in order to treat a leukemia.
ANSWER ALL QUESTIONS FULLY AND CORRECTLY
5-1 T cells recognize antigen when the antigen a. forms a complex with membrane-bound MHC molecules on another host-derived cell b. is internalized by T cells via phagocytosis and subsequently binds to T-cell receptors in the endoplasmic reticulum c. is presented on the surface of a B cell on membrane-bound immunoglobulins d. forms a complex with membrane-bound MHC molecules on the T cell e. bears epitopes derived from proteins, carbohydrates, and lipids. 5-2 a....
1 pts T cytotoxic cell activation involves: O antigen binding to antibody on B cells O T cell receptor (TCR) binding to antigen displayed in MHC-II O T cell receptor (TCR) binding to antigen displayed in MHC- natural killer cells 1 pts Question 13 Question 11 1 pts Which of the following is found on the surface of T cells! O All of these O MHC-II O CD and TCR TCR O CD 1 pts Question 12 Question 10 1...
5. Discuss the interaction between antigen receptor and epitope. 6. Describe the composition of T dependent and of T independent antigens
31. Which part of this T cell receptor is produced only AFTER the T cell has bound an antigen? A. The part labeled "A" B. The parts labeled "B" C. The entire T cell receptor D. None of it. It is all produced BEFORE antigen binding. E. T cells don't bind antigens; only antibodies do that. 37. How do Treg cells differ from Th cells? A. When Treg cells bind B7, they engulf and destroy it. B. Treg cells secrete...
B cell activation requires (select ALL that apply): O T cytotoxic cells O Tcell receptor (TCR) binding to antigen displayed in MHC-|| O antigen binding to antibody on B cell surface T cell receptor (TCR) binding to antigen displayed in MHC-I Question 3 1 pts Which statement(s) about C proteins in the complement system is true (select ALL that apply): Cproteins are always active as they circulate through the body All of the C proteins are equally important for all...
20. Defective function of which of the following proteins will result in failed antigen presentation to CD8 T cells? a. HLA-DM b. TAP c. Cathepsins d. CD1d 21.True or False: An antibody proteolytically cleaved by pepsin yields a fragment with higher avidity to the cognate antigen than an antibody cleaved by papain. a. True b. False 22.The structure recognized by an antibody (that is, the epitope) is the ________ and the regions of the antibody with significant sequence variation are...
Question 15 3 pts Null mutations in which of the following would allow antigen receptor production but reduce junctional diversity? Ligase O AID Tdt Rag2 Rag1 Question 16 3 pts What happens to centrocytes that have high-affinity (tightly binding) antigen receptors after somatic hypermutation? They receive survival signals from TFH cells They cannot process antigen or present it to TFH cells They undergo phagocytosis by dendritic cells in the "light zone" They die by apoptosis
3. Naïve T cells initially bind to antigen presenting cells by (T cell) binding to (APC) a. CD4 b. TCR c. CD36 d. LFA i. LFA ii. ICAM-1 i. MHC Class II iv. IL2 IV.
Which of the following statements about how B and T cells recognize antigen are true? Correct any false statements. a. B cells only recognize antigen presented by class I or class II MHC molecules. b. Both cell types can recognize extra-cellular antigen free-floating in solution. c. Both cell types recognize extracellular matrix-bound antigens. d. T cells only recognize antigen presented by class I or class II MHC molecules.