Pseudomonas aeruginosa secretes exos via its type 3 secretion. Exos has adp ribosylation and gap activity. How does the gap activity of exos (not the adp activity) help it to evade the host immune response?
ExoS is a bifunctional type III cytotoxin secreted by Pseudomonas aeruginosa, which has a C-terminal ADP ribosyltransferase domain and an N-terminal Rho GTPase-activating protein (GAP) domain.
Rho GTPases such as Rho, Rac, and Cdc42 helps in organization of the actin cytoskeleton.
Rho GTPases are preferred targets for bacterial toxins such as Exos and through is GAP activity it is modulating the organization of the actin skeleton and allowing invasion into nonprofessional cells and phagocytosis into professional phagocytes.
Pseudomonas aeruginosa secretes exos via its type 3 secretion. Exos has adp ribosylation and gap activity....
Pseudomas aeruginosa Exos effector toxin has a ADP ribosylation and GAP function. In its gap function, it acts as a Rho GAP for Rho, Rac, Cdc42 (What are the substrates for these three things) and how does the pathogen's gap function allow it to evade the immune response?
i need all the answers bug mosly i need #4,7&46 thank you 1) Bacteria containing the within their chromosomes function as the donors during conjugation and attach to the recipient cell via a A) F-plasmid: pilus B) R-plasmid : bacteriophage C) F-Factor : bacteriophage D) R-Factor: pilus E) F-Factor: pilus F) F-plasmid : bacteriophage 2) How does a plant's primary carbon source enter the leaf? A) Through the stomata B) Through the thylakoids C) Through the roots D) Through the...
Project 4-3: In the following steps, you will learn more about the PING (Packet Internet Grouper) utility, which can be used on a network running IPv4 to verify that TCP/IP is configured correctly and communicating with the network. A ping test is typically the first thing network professionals try when troubleshooting a TCP/IP connection problem. For this project, you can use any type of workstation that's running TCP/IPv4, preferably one connected to the Internet. The output described in the following...
Data List 1. Neural Growth Factor (NGF) is a secreted protein 2. P-STAT has a DNA binding site 3. Erk lives in the cytosol 4. P-Erk lives in the nucleus 5. Ras (which is a completely different protein than Ras-GEF) is a GTPase switch so on with GTP and off with GDP 6. Ras-GDP is located at the plasma membrane 7. TrkA has an amino acid that can have a phosphate group added to it (a phosphorylation site) 8. TrkA...
.matlab Objective: This activity has the purpose of helping students to to use either Simulink or VisSim to simulate the system behavior based on its Block Diagram representation and plot its response. Student Instructions: The following spring-mass-damper system has no external forcing, that is u(0)-0. At time t- 0 it has an initial condition for the spring, which it is distended by one unit: y(0)-1. The system will respond to this initial condition (zero-input-response) until it reaches equilibrium. 0)1initial condition...
Objective: This activity has the purpose of helping students to to use either Simulink or VisSim to simulate the system behavior based on its Block Diagram representation and plot its response Student Instructions: The following spring-mass-damper system has no external forcing, that is Lu(0) 0. At time t"0 it has an initial condition for the spring, which it is distended by one unit; yO) 1. The system will respond to this initial condition (zero-input-response) until it reaches equilibriunm. | yin«...
Please answer all parts of question number 3 and type them and bold or underline the correct answers Baker Mfg Inc. wishes to compare its inventory turnover to those of industry leaders, who have turnover of about 1313 times per year and 88 % of their assets invested in inventory. Baker Mfg. Inc. Net Revenue $27 comma 50027,500 Cost of sales $19 comma 41019,410 Inventory $1 comma 2901,290 Total assets $17 comma 82017,820 a) What is Baker's inventory turnover?...
Read the paper's abstract and discussion below. Answer these questions about the particle viral strategy in the paper a) Does this allow the virus to evadecthe innate or adaptive immune system( if adaptative, is it humoral or cell mediated b) How does the virus do this c) What viral protein is involved, if any d) What dpecific step in host defensevis affected e) what is the result Read the paper's abstract and discussion below. Answer these questions about the particular...
Immunology Question May you check my answers for 2a and 2b and see if: the information is being accurately presented, there is no unneeded information, and most importantly it is answering the question? I added more information to strengthen my answer so hopefully, it is better this time around. Thank you in advance! 2) Candida albicans is an opportunistic fungal pathogen in humans, and can cause a few irritating, but non- life threatening, infections in healthy individuals. However, in immunocompromised...