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Pseudomonas aeruginosa secretes exos via its type 3 secretion. Exos has adp ribosylation and gap activity....

Pseudomonas aeruginosa secretes exos via its type 3 secretion. Exos has adp ribosylation and gap activity. How does the gap activity of exos (not the adp activity) help it to evade the host immune response?

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ExoS is a bifunctional type III cytotoxin secreted by Pseudomonas aeruginosa, which has a C-terminal ADP ribosyltransferase domain and an N-terminal Rho GTPase-activating protein (GAP) domain.

Rho GTPases such as Rho, Rac, and Cdc42 helps in organization of the actin cytoskeleton.

Rho GTPases are preferred targets for bacterial toxins such as Exos and through is GAP activity it is modulating the organization of the actin skeleton and allowing invasion into nonprofessional cells and phagocytosis into professional phagocytes.

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