Homework Answers
- GPCR : G- protein coupling receptor
It help in the transmission of signals from extra cellular substance to G-protein
- RTK : Receptor tyrosine kinase
This receptor help in trasmembrane signaling .
- NRTK : Non-receptor tyrosine kinase
It regulate transfer of phosphate group from a nucleoside donor to tyrosine
- MAPK : Mitogen-activated protein kinase
It help in intracellular signalling .
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Match the abbreviation with its full name. GPCR A. Mitogen-activated protein kinases RTK B. Non-receptor tyrosine...
The insulin receptor is an example of a: A. GPCR. B. JAK-STAT receptor. C. receptor tyrosine...
The insulin receptor is an example of a: A. GPCR. B. JAK-STAT receptor. C. receptor tyrosine kinase. D. All of the above. E. A and B.
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of the...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Research and describe a cell receptor involved in cell signaling that utilizes one of the following...
Research and describe a cell receptor involved in cell signaling that utilizes one of the following mechanisms. 1. RTK pathway (Receptor Tyrosine Kinase Cascade) 2. GPCR (G Protein Coupled Receptor) 3. Ion Channel Receptors 4. Ligand Gated Your summary of the protein receptor must include the following: 1. Name of the receptor and its ligand. 2. A brief description of the pathway (what is activated and how). 3. Name of the pathway it is responsible for activating and what the...
Which one of the following statements is false? a. Many growth factor receptors are tyrosine kinases....
Which one of the following statements is false? a. Many growth factor receptors are tyrosine kinases. b. SH2 is an example of a protein domain that has high affinity binding for phosphorylated EGFR. c. Raf initiates a serine/threonine kinase cascade. d. Raf is activated by the kinase activity of RAS. Which one of the following statements is true? a. Retroviruses are a major cause of human cancers. b. Proto-oncogenes are altered forms of normal genes. c. Oncogenic activation of receptor...
Help with these bio questions please.Thank you 1 Secretory protein leave the cell by b Exoctossthey...
Help with these bio questions please.Thank you
1 Secretory protein leave the cell by b Exoctossthey remain in the cytoplasm c) pinocytosis d) receptor mediated 2 If proteins lack a c) Ras d) Signal-recognition particle b) Sorting signal 3 What purpose does the protein coat serve a) Capture molecules to remain in the cytosol b) Shapes the membrane into a phospholipid bilayer membrane c) Provides extra protection and support to the organelles d) none of these are correct cells response...
1. You are interested in how cyclic-AMP-dependent protein kinase A (PKA) functions to affect learning and...
1. You are interested in how
cyclic-AMP-dependent protein kinase A (PKA) functions to affect
learning and memory, and you decide to study its function in the
brain. It is known that, in the cells you are studying, PKA works
via a signal transduction pathway like the one depicted in Figure
16-15. Furthermore, it is also known that activated PKA
phosphorylates the transcriptional regulator called Nerd that then
activates transcription of the gene Brainy. Which, if any
of the situations described...
9. What happens when a trimeric G a. Ga separates from b. GB separates from the...
9. What happens when a trimeric G a. Ga separates from b. GB separates from the GaG protein is activated by the GpGy dimer dimer d. Ga, Gp, and Gy separate from each other e. The trimeric G protein localizes to the c. Gy separates from the GaGß dimer t nuceus se the folowing list to answer questions 10-13.Answers can be used more than once a. Endocytosis followed by degradation in lysosomes tqitination mediated by SOCS followed by degradation by...
You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that...
You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that all contain this receptor your drug has different effects. In cell type A you see activation of gene X and gene Y; in cell type B you note activation of Gene X, but no change in the mRNA levels for Gene Y. In cell type C your drug has no effect on either Gene X or Y. Describe how could each choice (A-D) be...
You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that...
You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that all contain this receptor your drug mas different effects. In cell type A you see activation of gene X and gene Y; in cell type B you note activation of Gene X, but no change in the mRNA levels for Gene Y. In cell type C your drug has no effect on either Gene X or Y. Describe how could each choice (A-D) be...
Hagrid has purified a protein from unicom sweat and called UNI-1. He has then doned the...
Hagrid has purified a protein from unicom sweat and called UNI-1. He has then doned the Unit gone and inserted in rat zygotes (by microinjection) a recombinant construct containing the Uni-1 coding sequence its entire 5 UTR region, covering both the minimal promoter and a series of cutative regulatory als elements. The mutantrats develop glorious, luminous hair. Hagrid has also discovered that the UNI-1 protein binds very tightly to DNA and hypothesizes it is a transcription factor that regulates proliferation...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Help with these bio questions please.Thank you
1 Secretory protein leave the cell by b Exoctossthey remain in the cytoplasm c) pinocytosis d) receptor mediated 2 If proteins lack a c) Ras d) Signal-recognition particle b) Sorting signal 3 What purpose does the protein coat serve a) Capture molecules to remain in the cytosol b) Shapes the membrane into a phospholipid bilayer membrane c) Provides extra protection and support to the organelles d) none of these are correct cells response...
1. You are interested in how
cyclic-AMP-dependent protein kinase A (PKA) functions to affect
learning and memory, and you decide to study its function in the
brain. It is known that, in the cells you are studying, PKA works
via a signal transduction pathway like the one depicted in Figure
16-15. Furthermore, it is also known that activated PKA
phosphorylates the transcriptional regulator called Nerd that then
activates transcription of the gene Brainy. Which, if any
of the situations described...
9. What happens when a trimeric G a. Ga separates from b. GB separates from the GaG protein is activated by the GpGy dimer dimer d. Ga, Gp, and Gy separate from each other e. The trimeric G protein localizes to the c. Gy separates from the GaGß dimer t nuceus se the folowing list to answer questions 10-13.Answers can be used more than once a. Endocytosis followed by degradation in lysosomes tqitination mediated by SOCS followed by degradation by...
You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that all contain this receptor your drug has different effects. In cell type A you see activation of gene X and gene Y; in cell type B you note activation of Gene X, but no change in the mRNA levels for Gene Y. In cell type C your drug has no effect on either Gene X or Y. Describe how could each choice (A-D) be...
You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that all contain this receptor your drug mas different effects. In cell type A you see activation of gene X and gene Y; in cell type B you note activation of Gene X, but no change in the mRNA levels for Gene Y. In cell type C your drug has no effect on either Gene X or Y. Describe how could each choice (A-D) be...
Hagrid has purified a protein from unicom sweat and called UNI-1. He has then doned the Unit gone and inserted in rat zygotes (by microinjection) a recombinant construct containing the Uni-1 coding sequence its entire 5 UTR region, covering both the minimal promoter and a series of cutative regulatory als elements. The mutantrats develop glorious, luminous hair. Hagrid has also discovered that the UNI-1 protein binds very tightly to DNA and hypothesizes it is a transcription factor that regulates proliferation...
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