Question

6. Describe why Parkinson's Disease creates a dyskinesia and how the basal ganglia pathways are involved.

Answer 1

I Describe why Parkinson's Disease creates a dyskinesia and how the basal ganglia pathways was involved . I Answer. Parkinson's Disease Dyskinesia in generally beleived to be caused by disease progression and the und of levodopa medications. As Parkinson's progresses, deteriorating p dopamene brain cells have increase difficulty in managing norinal movement - Since the patient use levodopa medications, the dyskinesia is thought to be the side effect of o levodopa use. Hon. Since Levodopa is intermittently taken over the course of a day, tlu level of clopamene will rise and fall These dopamine level fluctuations, in combination with the loss of dopaminergic neuren, and will lead to cause dyskenesia. - Basal ganglia motor cirenit in Parkinson's disease. dopaminergic neurons (DA) create a direct pateway between Substantia Nigra pars compacta (S Npc) and striatum - the input nuclei of the basal ganglia Indirect pathway increases its activity through STN in the output nudei and has inhibitory influence on the thalamus,

The basal ganglia circuitry processes the signals that flow from the cortex, allowing the correct excention of Noluntary movements. In Parkinson's disease, the degeneration of dopaminergie neurons of the substantia nigra pars compacta triggers a Cascade of fanctional changes affecting the whole basal ganglia network
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