The hunchback gene has an enhancer containing 3 binding sites for the transcription factor Bicoid. How...
The hunchback gene has an enhancer containing 3 binding sites for the transcription factor Bicoid. How could the loss of a single DNA binding site -leaving the 2 others intact- act to reduce gene expression of hunchback by more than 1/3 ?
A. Bound Bicoid transcription factor molecules interact antagonistically to cause maximal gene expression
B. Bound Bicoid transcription factor molecules interact additively to cause maximal gene expression
C. Bicoid does not bind to the hunchback enhancer
D. Bound Bicoid transcription factor molecules interact cooperatively to cause maximal gene expression
E. Hunchback could affect the expression of other developmental genes
Homework Answers
Answer: D. Bound Bicoid transcription factor molecules interact cooperatively to cause maximal gene expression.
Cooperative binding means binding at one site, enhances binding at the other sites. If one site loses the binding capability, then binding at other sites also gets affected. This is why binding is reduced by more than 1/3rd on mutation of just one site.
If it was additive binding of biocid, then expression would have reduced exactly by 1/3rd amount.
Antagonistic binding means binding at one site prevents binding at the other two sites. This would have brought down transcription and expression of hunchback levels.
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