Is drug concentration in plasma higher than in the serum? If so, why?
Is drug concentration in plasma higher than in the serum? If so, why?
Homework Answers
Yes, drug concentration in plasma is higher than in the serum because Blood is composed of red blood cells and plasma (RBCs). Serum is the substance that is collected from blood after being authorized to clot. Serum and plasma do not contain the same proteins. RBCs can be considered a cellular part of the body in which the concentration of the drug in the serum or plasma is in equilibrium, in the same way as with other body tissues.Whole blood samples are usually more difficult than serum or plasma samples to process and test. Plasma can be called a liquid tissue compartment in which the drug in the plasma fluid combines tissue and cellular components with drug.
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Is drug concentration in plasma higher than in the serum? If so,
why?
You want to achieve a particular plasma concentration of a drug of approximately 81 mg/L in...
You want to achieve a particular plasma concentration of a drug of approximately 81 mg/L in a 70 kg adult male. You know that the total volume of distribution for this drug is ~9L. What dose of drug should you give? (Choose the closest approximate value.) 5670 mg 729 mg correct 10 mg 9 mg In order to achieve the same plasma concentration of the above drug in an adult male who is obese (weighing 125 kg) but otherwise healthy,...
What is the difference between serum and plasma? Why does it matter in the laboratory if...
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Concentration of drug in plasma Time U2 C opyright © The President and Fellows of Harvard...
If 100 mg of a drug are administered intravenously, and the resultant drug plasma concentration is determined to be 2.5...
If 100 mg of a drug are administered intravenously, and the resultant drug plasma concentration is determined to be 2.5 ug/mL, calculate the apparent volume of distribution. The correct answer is 40 L. Please show how this question is solved.
Assuming that the bioavailability of this drug is 90% when taken orally and that the steady-state plasma concentration (...
Assuming that the bioavailability of this drug is 90% when taken orally and that the steady-state plasma concentration (Cpss) desired for this drug is 1mg/L, calculate the frequency, in hours, of dosing of pills containing 80mg of this drug.
ane Transport - Facilitated Diffusion Side with higher concentration of molecules Transport protein Plasma membrane Facilitated...
ane Transport - Facilitated Diffusion Side with higher concentration of molecules Transport protein Plasma membrane Facilitated diffusion causes a net movement of molecules down their concentration gradient. mework : Membrane Transport - Active Transport Side with higher concentration of square molecules Transport protein Energy input from the cell Plasma membrane Side with lower concentration of square molecules
4. Following a single dose of Phenytoin (anti-seizure drug) its peak concentration in plasma decreased to...
4. Following a single dose of Phenytoin (anti-seizure drug) its peak concentration in plasma decreased to 14.8 mcg/ml in 6 hours. Phenytoin elimination is zero order kinetics. Determine the initial concentration of the drug if its first half-life is 17 hrs.
QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion...
QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion of a 50 mg IV Bolus to a 42 year old subject. Drug A has a half-life of 6 hours and a volume of distribution of 25 liters
If a person had higher than normal levels of plasma proteins, would glomerular filtration rate increase,...
If a person had higher than normal levels of plasma proteins, would glomerular filtration rate increase, decrease, or stay the same? Assume that autoregulation is not occurring. Explain why GFR would change this way.
Explain why a weak acid solution has a higher pH than a strong acid solution concentration....
Explain why a weak acid solution has a higher pH than a strong acid solution concentration. of the same Explain why the equivalence point of a weak acid titrated with a strong base occurs at a basic pH.
ane Transport - Facilitated Diffusion Side with higher concentration of molecules Transport protein Plasma membrane Facilitated diffusion causes a net movement of molecules down their concentration gradient. mework : Membrane Transport - Active Transport Side with higher concentration of square molecules Transport protein Energy input from the cell Plasma membrane Side with lower concentration of square molecules
4. Following a single dose of Phenytoin (anti-seizure drug) its peak concentration in plasma decreased to 14.8 mcg/ml in 6 hours. Phenytoin elimination is zero order kinetics. Determine the initial concentration of the drug if its first half-life is 17 hrs.
QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion of a 50 mg IV Bolus to a 42 year old subject. Drug A has a half-life of 6 hours and a volume of distribution of 25 liters
If a person had higher than normal levels of plasma proteins, would glomerular filtration rate increase, decrease, or stay the same? Assume that autoregulation is not occurring. Explain why GFR would change this way.
Explain why a weak acid solution has a higher pH than a strong acid solution concentration. of the same Explain why the equivalence point of a weak acid titrated with a strong base occurs at a basic pH.
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