Assuming that the bioavailability of this drug is 90% when taken orally and that the steady-state plasma concentration (...
Assuming that the bioavailability of this drug is 90% when taken orally and that the steady-state plasma concentration (Cpss) desired for this drug is 1mg/L, calculate the frequency, in hours, of dosing of pills containing 80mg of this drug.
Homework Answers
DOSE FREQUENCY is the number of times a substance is administered within a specific period of time or administered per a specific interval.
To calculate the frequency of dosages in hours, the formula is
D (DESIRED DOSE) X V (VEHICLE - FORM AND AMOUNT OF DRUG) DIVIDED BY H (DRUG ON HAND). Let us take desired dose as 1mg, vehicle as 1litre which is equal to 1000 ml and drug on hand as 80 mg. Therefore, it will be 1 x 1000 divided by 80 = 12.5
Add Answer to:
Assuming that the bioavailability of this drug is 90% when taken orally and that the steady-state plasma concentration (...
can anyone help me solve this pharmokientics question Part 1 of 2 12. A steady-state plasma...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient....
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient. The drug has a half-ife of 12 hours and a volume of distribution of 75 L. Calculate the loading dose in mg.
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
oA physician wishes to administer an anti-arrhythmic drug via multiple IV bolus doises to a patient...
oA physician wishes to administer an anti-arrhythmic drug via multiple IV bolus doises to a patient for the immediate treatment of ventricular arrhythmia. Calculate a recommended loading dose and suitable dosing regimen that would maintain a maximum and minimum steady concentration of 20 and 10 mg/L respectively for this drug. The drug has a half life of 11 hours and a VD 30 L A. What is your recommended loading dose B. What would be the appropriate dosing interval for...
When 800 mg of a new drug under study is administered IV in normal volunteers, 800...
When 800 mg of a new drug under study is administered IV in normal volunteers, 800 mg are recovered unchanged in urine. The AUC obtained after IV injection is 400 mg.h/L and the half life is 8 hours. When 400 mg are orally administered in volunteers 350 mg of drug are recovered unchanged in urine. Calculate: K, Kr, Vd, and oral bioavailability (F). thats all the data i have
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F - 0.02; fe - 0.03; t 2-4 hours; Vd- 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL. a. Calculate the infusion rate necessary to maintain b. Calculate how long it will take to reach 90% of c. Calculate the loading dose. a steady state plasma concentration of 3 ug/mL steady state
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose of an antibiotic every 6 hours by repetitive IV injection (ouch!). The drug has a Vo of 20 L and an elimination half-life of 3 hours. Ct (post ss) = xon-e-ke x e-kt
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then...
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient. The drug has a half-ife of 12 hours and a volume of distribution of 75 L. Calculate the loading dose in mg.
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
oA physician wishes to administer an anti-arrhythmic drug via multiple IV bolus doises to a patient for the immediate treatment of ventricular arrhythmia. Calculate a recommended loading dose and suitable dosing regimen that would maintain a maximum and minimum steady concentration of 20 and 10 mg/L respectively for this drug. The drug has a half life of 11 hours and a VD 30 L A. What is your recommended loading dose B. What would be the appropriate dosing interval for...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F - 0.02; fe - 0.03; t 2-4 hours; Vd- 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL. a. Calculate the infusion rate necessary to maintain b. Calculate how long it will take to reach 90% of c. Calculate the loading dose. a steady state plasma concentration of 3 ug/mL steady state
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose of an antibiotic every 6 hours by repetitive IV injection (ouch!). The drug has a Vo of 20 L and an elimination half-life of 3 hours. Ct (post ss) = xon-e-ke x e-kt
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
Most questions answered within 3 hours.
-
Assume that the population of Mexico is 128
million and that the population increases 1.01
percentannually....
asked 51 minutes ago -
Can someone please help me add appropriate descriptive
comments to each line of code in the...
asked 57 minutes ago -
Romeo wishes to throw a bouquet of flowers to Juliet, who is on
a second-story balcony,...
asked 1 hour ago -
Why is QE a controversial monetary policy tool.
A. It may lead to excessive inflation.B. By...
asked 2 hours ago -
Principles of Programming midterm study guide help!
1.)
______ Which of the following would reference the...
asked 1 hour ago -
A finite potential well has depth U0 = 2.78 eV . What is the
penetration distance...
asked 2 hours ago -
1. The bus bars of a power station are in two sections A and B
separated...
asked 2 hours ago -
Fiscal policy is the deliberate manipulation of taxes and
government spending to alter GDP, employment, inflation...
asked 3 hours ago -
evaluating an expression using only one digit and + and - as
operators ....3+5-1+7-5+8
-----------------------
stack...
asked 3 hours ago -
Two concentric current loops lie in the same plane. The smaller
loop has a radius of...
asked 4 hours ago -
1)Which of the following is an
important difference between qualified and nonqualified retirement
plans?
a. Qualified...
asked 4 hours ago -
What's the streaming business's problem on the
horizon?
asked 5 hours ago