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If you have an enzyme that has a primary sequence that is 429 amino acids in...

If you have an enzyme that has a primary sequence that is 429 amino acids in length, is it possible that both an amino acid position 215, as well as amino acids located at 342, and 401, can all be part of an active site of a protein? Explain why or why not?

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Answer #1

Answer: Yes

Explanation:

Proteins are heteropolymers of amino acids linked together by peptide bonds. Proteins exhibit various levels of structural organization.
Primary structure: The linear sequence of amino acids linked together by peptide bonds
Secondary structure: Local conformation of the polypeptide backbone Ex: Alpha helix and beta sheet
Tertiary structure: Overall #-dimensional conformation of the protein
Quaternary structure: Interactions among individual subunits in a multimeric protein

In the tertiary structure of a protein, the polypeptide chain is folded in a 3-dimensional manner so that amino acids that are far apart in the linear sequence can be brought adjacent to each other. Active site of many proteins contains amino acids that are far aprt in the linear sequence but are brought together by folding in 3D structure.

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