Processing of proteins is subject to quality control within the ER, which prevents improperly folded proteins...
Processing of proteins is subject to quality control within the ER, which prevents improperly folded proteins from reaching the cell surface. What are the typical fates of the misfolded proteins and which proteins play a role in this process?
Homework Answers
The misfolded or unfolded proteins will be disaggregated by disaggregating chaperones. These Chaperones favor the native protein folding by either as unfoldases, powerfully unfolding and untangling misfolded polypeptides from folded or aggregated proteins, or as holdase, requisition hydrophobic sites in misfolding polypeptides.
The HSP (heat shock proteins) 60,70, 90, and 100 are typically involved with the chaperones for the disaggregation of the unfolded proteins. Unfolding, stabilization of extended chains, disaggregation, folding, translocation across the membranes of the organelles, targeting substrates for degradation, regulation of the heat-shock reaction are the main functions of the HSP proteins.
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Processing of proteins is subject to quality control within the
ER, which prevents improperly folded proteins...
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all please 2. Which of the following is an example of posttranslational modification? a. Glycosylation b....
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2. Which of the following is an example of posttranslational modification? a. Glycosylation b. Protcolysis c. Palmitoylation d. All of the above 3. The growing polypeptide chain coming off the ribosomal complex is fairly unstable. It has a tendency to fold back on itself and can aggregate with adjacent polypeptides, and these processes, if allowed to occur, would yield degraded, improperly folded, or large aggregates of nonfunctional proteins. How does the cell prevent this from occurring? 4. Transcriptionally...
Which of the following statements describing the import of proteins into the nucleus is correct? Answers A-D A Transport into the nucleus requires the activity of a G protein. B The receptor for nuclear proteins is found in the cytosol and travels into the nucleus with the protein being transported o С Proteins destined for the nucleus are transported in a fully-folded conformation. D These statements are all correct. o You are interested in a water-soluble protein that functions within...
The liver is involved in detoxification of many poisons and drugs. Which of the following structures is primarily involved in this process and therefore abundant in liver cells? A) rough ER B) smooth ER C) Golgi apparatus D) nuclear envelope E) transport vesicles Which of the following produces and modifies polysaccharides that will be secreted? A) lysosome B) vacuole C) mitochondrion D) Golgi apparatus E) peroxisome Which organelle often takes up much of the volume of a plant cell? A)...
The transporter in antigen processing genes encode subunits of a heterodimer pump that transports peptides from the cytosol into the endoplasmic reticulum, where they can associate with newly translated Class la chains O B-2 microglobulin. Proteosomes. Immunoglobulin molecules. Class Il a and B chains. Question 20 5 pts Soluble proteins are examples of: Bone marrow dependent antigens. Bone marrow independent antigens., Thymus dependent antigens. Thymus independent antigens. Good food. The features of bound peptide fragments isolated from different class molecules...
please answer question46, 47,49,50, 52, 53
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