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Show how NADH is recycled to NAD+ under anaerobic conditions. Why is it important to recycle...

Show how NADH is recycled to NAD+ under anaerobic conditions. Why is it important to recycle NADH produced during glycolysis to NAD+?

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Answer #1

During anaerobic conditions, pyruvate is reduced to lactate. The reduction is catalyzed by lactate dehyrdogenase, giving L-isomer of lactate at pH 7.

Failure to regenerate NAD+ would leave the cell with no electron acceptor for the oxidation of glyceraldehydes-3 phosphate. This will end the energy-yielding reactions of glycolysis. Hence NAD+ must be regenerated in any way.

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