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explain how you can guess if a specific protein is a transmembrane protein.

explain how you can guess if a specific protein is a transmembrane protein.

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Transmembrane proteins are the proteins that are present in the plasma membrane. The plasma membrane is an amphipathic structure. It has a hydrophilic head group and hydrophobic tail group. Any protein that is present in the plasma membrane has to pass through the hydrophobic tail.

Based on the polarity amino acid are divided into polar and non-polar amino acid. The non-polar amino acid is hydrophobic in nature and interacts with each other by hydrophobic interactions. Tail group of the plasma membrane are also hydrophobic. So hydrophilic amino acid can make the transmembrane domain.

If we want to guess if the specific protein has a transmembrane domain then we need to look for a stretch of hydrophobic amino acid. If the stretch is present then we can guess that protein is a transmembrane protein.

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