Please help!!!! Any explanation would be much appreciated! Which scenario do think is the most likely...
Please help!!!! Any explanation would be much appreciated!
Which scenario do think is the most likely to lead to malignancy and Cancer? Assume K-Ras and TSC1/2 in these scenarios are wild-type.
a. a mutation in SOS that eliminates its interaction with K-Ras
b. a mutation in TSC1/2 that eliminates its interaction with RheB
c. a mutation in GAP that causes it to be always associated with K-Ras
d. none of these could lead to Cancer
Homework Answers
C. A mutation in GAP that causes it to be always associated with k-Ras.
( As k-Ras and TSC1/2 are wild type, so no mutation in these gene. But mutation in upstream or downstream of it like, GAP mutation induced the pathway always active and leads to cancer.)
Thank you............
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