Which of the following G protein subunits activate K+ channels in response to the GPCR for...
Which of the following G protein subunits activate K+ channels in response to the GPCR for acetylcholine on heart muscle?
G beta gamma dimer
G alpha stimulatory
G alpha transducin
Galpha inhibitory
Homework Answers
Answer (A) G beta gamma dimer is the G protein
subunit which activate K+ Channels in response to the GPCR for
Acetylcholine on heart muscle.
G protein is made up of the three subunits α, βand γ. Muscarinic receptors such as those found in heart muscle are classified as G protein coupled receptors (GPCR)
Binding of acetylcholine Binds to the muscarinic acetylcholine
receptors in heart muscle which causes dissociation of the coupled
trimeric G protein.
The released Gβ,γ subunit now binds to and opens a K+ channel protein. Due to this, K+ ions move inside and hyperpolarizes the cell membrane. It ultimately slows down the heart contraction.
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