Question

In types of gene mapping (the main two linkage and physical)

Are FISH, Radiation hybrid, chromosomal, cytogenic, Restriction mapping, all subtypes of physical mapping? or are they all different types?

Answer 1

Answer:-

Physical mapping is basically based on the DNA sequences or by the physical distance within the landmarks in DNA sequence on a chromosome. There are generally various types of physical maps are present. Some of them include Radiation hybrid maps, Restriction maps, cytogenic maps, chromosomal maps, Sequence tagged sites maps, Contig maps (Contig means contiguous). But in general there are three types of physical mapping , one is radiation hybrid mapping, Sequence mapping and cytogenic or chromosomal mapping.

For the production of physical mapping some method are being enrolled i.e FISH (fluorescent insitu hybridization), Restriction mapping and sequence tagged sites mapping. Physical mapping have lot of applications. They help in the confirmation of linkages. They are able to ptovide detailed comparisons of regions of co-localization of genetic loci between the genomes.

Hope the above answer comes up to your expectation. Please do come up with your feedback.