Why 5-fluorouracil can inhibit thymidylate synthase?
Why 5-fluorouracil can inhibit thymidylate synthase?
Homework Answers
5-flurouracil is structural analog of pyrimidine bases (uracil, thymidine, and cytosine) thus it bind with thymidylate synthase and prevent the formation of thymidine base. Hence inhibit the natural action of enzyme.
Thymidylate synthase To understand how fluorouracil works, let's first take a look at how a cancer cell divides. A...
Thymidylate synthase To understand how fluorouracil works, let's first take a look at how a cancer cell divides. An enzyme called thymidylate synthase must convert deoxyuridinemonophosphate (dUMP) to deoxythymidinemonophosphate (dTMP). One of the steps in this multistep process is an elimination reaction, which is shown below. RIH Elimination 052- DNA Growth / Cancer Spreads made from DUMP Enzyme Identify the role of the nitrogen substituent shown in blue. C zor made from DUMP Enzyme C C C Identify the role...
Answer the following two questions. Statins, such as lovastatin. competitively inhibit one of the enzymes of...
Answer the following two questions. Statins, such as lovastatin. competitively inhibit one of the enzymes of cholesterol synthesis. The structure of lovastatin is given below. Which enzyme does it inhibit? smallcircle HMG-CoA synthase smallcircle HMG-CoA reductase smallcircle pyrophosphomevalonate decarboxylase smallcircle squalene synthase
Calculate the hepatic clearance (Umin) of the drug 5-fluorouracil (fus 90%; fex < 196; V-18 L...
Calculate the hepatic clearance (Umin) of the drug 5-fluorouracil (fus 90%; fex < 196; V-18 L ; t1/2 = 1 1 min.
The cancer drug 5-fluorouracil is a weak acid with a logP if about -0.6. Which of...
The cancer drug 5-fluorouracil is a weak acid with a logP if about -0.6. Which of the following is true with respect to the effect of pH on apparent partition coefficient for 5-fluoruracil? Papp should increase with increasing pH Papp should decrease with increasing pH Papp will not change with increasing pH
4. Briefly (one or two sentences) explain why polyamides (shown below) can inhibit gene transcription. (2...
4. Briefly (one or two sentences) explain why polyamides (shown below) can inhibit gene transcription. (2 points) Recognition of All 4 Base Pairs go w
Describe 5 ways you, as a health professional, can help to slow or inhibit bacteria resistance.
Describe 5 ways you, as a health professional, can help to slow or inhibit bacteria resistance.
Why is citrate synthase a good candidate for a regulatory enzyme?
Why is citrate synthase a good candidate for a regulatory enzyme?
3.23 QUESTION 20 Explain why an antibiotic you might take can target and inhibit translation in...
3.23 QUESTION 20 Explain why an antibiotic you might take can target and inhibit translation in bacteria (prokaryotes), but not affect translation in your own eukaryotic cells. TTTT Paragraph Arial • 3 (12pt) E. T %DOQ O Sx Mashups T' T. HTML CSS Words:0 Path:P
Explain why compounds that inhibit the activity of bacterial topoisomerase are used as antibiotics.
Explain why compounds that inhibit the activity of bacterial topoisomerase are used as antibiotics.
Why are most compounds that inhibit enzymes of the electron transport chain lethal?
Why are most compounds that inhibit enzymes of the electron transport chain lethal?
Thymidylate synthase To understand how fluorouracil works, let's first take a look at how a cancer cell divides. An enzyme called thymidylate synthase must convert deoxyuridinemonophosphate (dUMP) to deoxythymidinemonophosphate (dTMP). One of the steps in this multistep process is an elimination reaction, which is shown below. RIH Elimination 052- DNA Growth / Cancer Spreads made from DUMP Enzyme Identify the role of the nitrogen substituent shown in blue. C zor made from DUMP Enzyme C C C Identify the role...
Answer the following two questions. Statins, such as lovastatin. competitively inhibit one of the enzymes of cholesterol synthesis. The structure of lovastatin is given below. Which enzyme does it inhibit? smallcircle HMG-CoA synthase smallcircle HMG-CoA reductase smallcircle pyrophosphomevalonate decarboxylase smallcircle squalene synthase
Calculate the hepatic clearance (Umin) of the drug 5-fluorouracil (fus 90%; fex < 196; V-18 L ; t1/2 = 1 1 min.
4. Briefly (one or two sentences) explain why polyamides (shown below) can inhibit gene transcription. (2 points) Recognition of All 4 Base Pairs go w
3.23 QUESTION 20 Explain why an antibiotic you might take can target and inhibit translation in bacteria (prokaryotes), but not affect translation in your own eukaryotic cells. TTTT Paragraph Arial • 3 (12pt) E. T %DOQ O Sx Mashups T' T. HTML CSS Words:0 Path:P
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