Question

In response to an apoptotic stimulus, initiator caspases a. degrade procaspases. b. cleave a transcription factor...

In response to an apoptotic stimulus, initiator caspases

  1. a.

    degrade procaspases.

    b.

    cleave a transcription factor to active gene expression.

    c.

    degrade executioner caspases.

    d.

    cleave and activate executioner caspases.

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Answer #1
  • The right answer is option d - cleave and activate executioner caspases.
  • Once activated, the initiator caspases cleave effector caspases. Without the presence of a big pro-domain, effector caspases (caspases-3,6, and 7) do not need an adaptor protein for dimerisation-induced activation.
  • Instead, effector caspases spontaneously dimerise.
  • Activated effector caspases then cleave a number of protein substrates to initiate the process of apoptosis.
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